1991年5月1日 · Infection of captive macaques with simian immunodeficiency virus (SIV) and domestic cats with feline immunodeficiency virus (FIV), both discovered in the last five years, represent excellent animal models for infection of humans …

Feline immunodeficiency virus (FIV) is one of the most common and consequential infectious diseases of cats around the world. In infected cats, FIV attacks the immune system, leaving the cat vulnerable to many other infections.

2024年11月15日 · 慢病毒是逆转录病毒的一种，它之所以称为慢病毒，是因为这些病毒具有长达数年的潜伏期，其中人HIV，猴SIV，猫FIV都是慢病毒。 慢病毒和逆转录病毒典型特征为其 RNA 基因组能逆转录为 cDNA 副本，cDNA 副本又能稳定整合至宿主细胞基因组中（这就是常说的稳转）。 逆转录病毒通常分两种：简单的（如γ-逆转录病毒，如MMLV、MSCV等）和复杂的（如慢病毒）。 当科学家们讨论逆转录病毒时，他们通常指的是γ-逆转录病毒。 图1. 逆转录病毒的结 …

Feline immunodeficiency virus (FIV) is an important cat pathogen worldwide whose biological and pathophysiological properties resemble those of human immunodeficiency virus type 1 (HIV-1). Therefore, the study of FIV not only benefits its natural ...

2011年11月9日 · Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection.

Feline immunodeficiency virus (FIV) is a retrovirus of worldwide distribution that can cause an acquired immunodeficiency disease in domestic cats. FIV and the primate lentiviruses, human and simian immunodeficiency viruses (HIV and SIV, respectively) share structural and biological features but als …

2020年5月1日 · Infection of captive macaques with simian immunodeficiency virus (SIV) and domestic cats with feline immunodeficiency virus (FIV), both discovered in the last five years, represent excellent animal models for infection of humans …

Feline immunodeficiency virus (FIV) is an important viral pathogen worldwide in the domestic cat, which is the smallest animal model for the study of natural lentivirus infection. Thus, understanding the molecular mechanisms by which FIV carries out ...

SIV infection of the central nervous system of macaques now provides the best animal model for HIV infection of the human brain due to the close evolutionary relationship between monkeys and man, the genetic relatedness of their respective lentiviruses, and the similarities in the neuropathology.

2018年4月20日 · Given these similarities (and limitations of the SIV model), FIV represents an adjunct lentiviral model that can accurately recapitulate neuroAIDS progression in HIV-infected humans for applications, such as evaluation of ART-induced neurotoxicity, neurofibrillary tangle development, and calcium homeostasis during viral infection [14,17].