2021年3月26日 · The strong correlation between type 1 cDC (cDC1) infiltration of human cancers with overall survival in many cancer types suggests the potential use of Flt3L to boost expansion of this DC subset. However, this may need the combination of Flt3L with other immunomodulatory agents to boost cancer immunotherapy.

In this review, Flt3 is discussed with a particular focus on DCs. We detail the lifecycle of Flt3, from transcription to degradation, and interrogate recent studies as to how this pathway can be manipulated for immunotherapy, vaccination and treatment of autoimmune disease.

Flt3L/Flt3 is an essential pathway for DC development and function, although its potential in cancer immunotherapy is not yet clearly established. Herein, we will review the current evidence which suggests that the stimulation of DCs through the Flt3/Flt3L axis may contribute to improved cancer immunotherapy.

2024年5月1日 · Flt3 is critical for DC development, but it is unclear how Flt3 expression and signaling impacts terminally differentiated cDCs. In this study we investigated Flt3 expression and determined how constitutive Flt3 signaling downstream as a result of the ITD mutation impacts DC number, phenotype and function.

2023年12月19日 · FLT3-L-dependent classical dendritic cells (cDCs) recruit anti-tumor and tumor-protecting lymphocytes. We evaluate cancer growth in mice with low, normal, or high levels of cDCs. Paradoxically, both low or high numbers of cDCs improve survival in mice with melanoma.

2023年8月8日 · In this study, using fate mapping models, single-cell RNA sequencing (scRNA-seq), and adoptive transfer, we showed that the FLT3+ CD11c − R2 cells are DC progenitors that derive directly from Ly6C + MDPs and predominantly give rise to a CD172a + CD16/32 + DC population that we named “DC3”.

In this review, Flt3 is discussed with a particular focus on DCs. We detail the lifecycle of Flt3, from transcription to degradation, and interrogate recent studies as to how this pathway can be manipulated for immunotherapy, vaccination and treatment of autoimmune disease.

2008年5月11日 · Here we report on the function of Flt3 in DC development in the bone marrow and in peripheral lymphoid organs and show that it is an important regulator of homeostatic DC division in the...

2020年5月18日 · Here, we engineered T cells to secrete the dendritic cell (DC) growth factor Fms-like tyrosine kinase 3 ligand (Flt3L). Flt3L-secreting T cells expanded intratumoral conventional type 1 DCs and...

2024年8月20日 · In this study, results from single-cell sequencing data analysis revealed a clear relationship between FLT3 + DCs and Regulatory T cells (Tregs) in liver tissue of LT recipients. In peripheral blood samples of LT patients, levels of FLT3 + DCs were decreased post-LT-surgery, while Tregs were increased.