
Bruker FM: MIR-FIR/THz in one go
业内独家领先的Bruker FM一次测量中远红外全谱功能(6000-50 cm -1)能够让您在鉴定样品成分的同时筛查鉴别其固态形式。 只需一次测量即可获得中、远红外区域的全部光谱信息。 阅读我们的应用文献《Bruker FM Wide Range FIR-MIR Spectroscopy》. 远红外和太赫兹波段的光谱对无机物的研究极为重要。 无机物中很多重原子的振动会体现在远红外400cm -1 以下的光谱中。 结合Bruker FM功能,我们的VERTEX 70v 和 INVENIO R傅里叶变换光谱仪能帮助您轻松简单地得 …
Oncogene | 首创MicroRNA靶向治疗肿瘤 - 知乎 - 知乎专栏
2023年9月11日 · 普渡大学(Purdue University)的研究人员开发了一种新型癌症疗法,该疗法使用一种经过修饰的 microRNA miR-34a 来阻止癌细胞分裂。在小鼠的临床前试验中,使用完全修饰的靶向肿瘤的miR-34a治疗在21天的评估期内停止了肿瘤生长,并导致一些动物完全治愈。
普渡大学研究团队成功开发叶酸靶向的miR-34a疗法 - 网易
2023年9月28日 · 近日,普渡大学的研究人员已经开发出一种新型的癌症治疗方法,利用修改过的微RNA(miR-34a)来阻止癌细胞的分裂。在小鼠的临床前测试中,使用完全修改的、针对肿瘤的miR-34a治疗在21天的评估期内停止了肿瘤的生长,并在某些动物中完全治愈。
A first-in-class fully modified version of miR-34a with ... - Nature
2023年9月5日 · Here, we highlight a fully modified version of miR-34a (FM-miR-34a) that overcomes these hurdles when conjugated to a synthetically simplistic ligand. FM-miR-34a is orders of magnitude more...
完全修饰miR-34a microRNA治疗成功减缓肿瘤生长 miRNA药物再 …
2023年9月7日 · 通过将FM-miR-34a偶联叶酸(FM-FolamiR-34a)可实现体内靶向,能够抑制肿瘤生长,从而在小鼠中完全治愈肿瘤。 这些结果有望重振miR-34a作为抗癌药物的希望,为临床试验提供了强有力的理论依据。
Brochure BRUKER FM
In 2014, Bruker introduced the world’s first FT-IR spectrometer technology capable of covering the FIR/THz and MIR in a single scan, named Bruker FM. No exchange of optical components or merging of spectra is needed to obtain data from the FIR/THz through the MIR.
Weldon School of Biomedical Engineering最新研究:一种首款完全修饰的miR …
本研究提出了一种全修饰版本的miR-34a(FM-miR-34a),该版本能够有效地克服miR-34a的不稳定性和传递难度大等问题。 通过将FM-miR-34a与一种简单的合成配体结合,可以实现FM-miR-34a的传递和靶向。
A first-in-class fully modified version of miR-34a with ... - PubMed
2023年9月5日 · FM-miR-34a potently inhibited proliferation and invasion, and induced sustained downregulation of endogenous target genes for >120 h following in vivo delivery. In vivo targeting was achieved through conjugating FM-miR-34a to folate (FM-FolamiR-34a), which inhibited tumor growth leading to complete cures in some mice.
GEO Accession viewer - National Center for Biotechnology …
FM-miR-34a is orders of magnitude more stable than a partially modified version, without compromising its activity, leading to stronger repression of a greater number of miR-34a targets. FM-miR-34a potently inhibited proliferation and invasion, and induced sustained downregulation of endogenous target genes for >120 hours following in vivo ...
Bruker FM: MIR-FIR/THz in one go
The unique Bruker FM technology offers the measurement of the complete FIR-MIR spectral range in one step and allows for simultaneous identification and polymorph screening of samples. MIR region covering fundamental molecular vibrations for the identification of the substance