Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development.

The Pediatric Endocrine Society recently published new guidelines for the use of growth hormone (hGH) and insulin-like growth factor-I (hIGF-I) treatment for GH deficiency (GHD), idiopathic …

In consequence, we selected acromegaly and Laron syndrome due to GH receptor deficiency (GHRD) as models for excess and absence of GH action, and focused in the role of GH/GHR signaling in the genesis of cancer and diabetes.

Human growth hormone (hGH or GH) is a protein produced in the body that's important not only during childhood but also throughout adulthood. Growth hormone is produced by the pituitary gland, which is known as the "master gland" because it secretes many hormones that control the actions of other glands.

2023年3月30日 · GH stimulates the aerobic and anaerobic energy systems that underpin muscle and cardiovascular function. These pleiotropic actions explain the clinical picture of increased adiposity, reduced lean mass, and impaired physical and psychological function in the GHD adult, all of which are reversed when GH is replaced.

Although IGFD can develop at any level of the GHRH-GH-IGF axis, a differentiation should be made between GHD (absent to low GH in circulation) and IGFD (normal to high GH in circulation). The main focus of this review is on the GH-gene, the various gene alterations and their possible impact on the pituitary gland.

Insulin-like Growth Factor I (IGF-I) inhibits GH secretion by a negative loop at both hypothalamic and pituitary levels. In addition, age, gender, pubertal status, food, exercise, fasting, sleep and body composition play important regulatory roles.

Many of the actions of growth hormone (GH) on somatic growth and tissue maintenance are mediated by insulin-like growth factor-I (IGF-I), a secreted protein whose gene expression is rapidly and potently induced by GH by unknown mechanisms.

Individuals surviving cancer and brain tumors may experience growth hormone (GH) deficiency as a result of tumor growth, surgical resection and/or radiotherapy involving the hypothalamic-pituitary region.

GH is a polypeptide hormone exhibiting molecular heterogeneity. It consists of a complex mixture of molecular isoforms and their multimers. In humans, the genetic locus that codes GH resides on chromosome 17q24.2 [4, 5], has 46.83 kilobases and contains five GH related genes. These multiple genes most likely arose from gene duplication.