Through cell biology and proteomic analyses, muscle-specific FN1 depletion, and liver-specific α5 integrin depletion in mouse models, we discover a previously uncharacterized FN1-α5β1 integrin-IKK-JNK1-BECN1 pathway that regulates exercise-induced muscle-liver communication, systemic autophagy activation, and whole-body metabolic improvement.

2025年3月30日 · FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include Spondylometaphyseal Dysplasia, Corner Fracture Type and Glomerulopathy With Fibronectin Deposits 2. Among its related pathways are Signaling downstream of RAS mutants and Integrin Pathway.

2020年6月19日 · Here we report that fibronectin 1 (FN-1) promoted differentiation and mineralization of osteoblasts by activating WNT/β-catenin pathway, in cultured pre-osteoblasts. With isobaric tags for...

2021年3月17日 · Here we remark the fundamental role of fibronectin (FN1) as a key component of ECM and of its fibrillogenesis, a cytoskeleton contractility dependent process, which initiates the ECM elaboration and contributes to ECM architecture, responsible for the bioavailability of growth factors and cytokines.

Our study shows that FN1 expression is closely related to tumor-infiltrating immune cells including macrophages, NK cells, Treg cells, CD8+ T cells, and DCs. At the same time, we have studied that the expression of FN1 is associated with immune checkpoints as well as …

2025年2月13日 · Arriagada et al. report that the extracellular matrix (ECM) protein fibronectin (FN1) synthesized by the mesoderm affects multiple cell behaviours in the dorsal pericardial wall of the...

2020年7月31日 · Inhibition of FN1 expression significantly reduced proliferation, migration, invasion and EMT processes of GC cells, and enhanced cell apoptosis. These results confirm that FN1 is up-regulated in GC, thereby functioning as an oncogenic gene.

The findings of this study provide evidence highlighting the prominent role played by FN1 in stimulating glioma growth, invasion, and survival through the activation of the PI3K/AKT signaling pathway.

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein.

2022年8月23日 · Fibronectin 1 (FN1) is a glycoprotein found throughout the extracellular matrix that has a role in the onset and progression of cancer. However, its immune relationship with gastric cancer is still unclear. FN1 was systematically reviewed by Gene Expression Profiling Interactive Analysis (GEPIA), Li …