2018年12月17日 · A reduction in mRNA and protein levels of 5 SOX9 targets, namely Opn, Gpnmb, Fn1, Sparc, and Vim was uncovered (Fig. 2B–D). Compared to quiescent HSC controls, transcript and protein levels were increased in activated HSCs (Fig. 2E–G ).

2022年12月1日 · The upregulation of FN1, SOX9 was observed during atherosclerosis. And the higher expression of SOX9 and lower expression of FN1 were shown in AAV-sgIL-1β group, compare with AS-16 weeks...

2024年9月1日 · We investigated the role of SOX9 in TGF-β1-induced fibroblast activation and ECM deposition in rat tracheal fibroblast (RTF) cells. SOX9 overexpression adenovirus (Ad-SOX9) and siRNA were transfected into RTF cells. We found that SOX9 expression was up-regulated in RTF cells treated with TGF-β1.

2024年2月28日 · Overexpression of Sox9 induced the expression of Ccn2 or Fn1 in ECs that coexpressed one or both endothelial markers (fig. S27G). These results indicated that endothelial SOX9 overexpression caused mesenchymal gene activation in ECs, but endothelial identity remained largely preserved.

2025年1月4日 · SOX9 plays a crucial regulatory function in breast cancer, specifically in the triple-negative breast cancer (TNBC) subtype. It influences both survival and metastasis. In vitro experiments have shown that experimental suppression of SOX9 inhibits the proliferation and invasion of TNBC cells; its depletion induces substantial apoptosis.

2017年7月19日 · We show that SOX9 is induced in response to ischemic injury and that in vivo loss of SOX9 after myocardial infarction blunts the cardiac fibrotic response on damage, revealing a previously unknown function for SOX9 in cardiac fibrosis.

2015年7月6日 · Using the RCS cell line as a faithful model for proliferating/early prehypertrophic growth plate chondrocytes, we uncover that SOX6 and SOX9 bind thousands of genomic sites, frequently and most efficiently near each other. SOX9 recognizes pairs of inverted SOX motifs, whereas SOX6 favors pairs of tandem SOX motifs.

2018年12月17日 · In this study, transcriptomic approaches of Sox9-abrogated myofibroblasts identified >30% of genes regulated by SOX9 relate to the ECM. Further scrutiny of these data identified a panel of highly expressed ECM proteins, including Osteopontin (OPN), Osteoactivin (GPNMB), Fibronectin (FN1), Osteonectin (SPARC) and Vimentin (VIM) as SOX9 targets ...

The expression of the differentiation and stemness genes, FN1 and SOX9, is accompanied by cell proliferation. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.

SOX9 enrichment (IP) is shown for Fn1, Gpnmb, Sparc and Spp1 (Opn). from publication: SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver...