Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. [5][6][7] FOXA1 is a member of the forkhead domain transcription factor family.

2024年12月25日 · FOXA1 (Forkhead Box A1) is a Protein Coding gene. Diseases associated with FOXA1 include Prostate Cancer and Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are ESR-mediated signaling and Gastrulation.

2024年4月11日 · FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including...

2023年12月19日 · 近日，首都医科大学基础医学院陈萍教授团队与清华大学王亮博士在《Molecular Cell》上发表题为“FOXA1 Forms Biomolecular Condensates that Unpack Condensed Chromatin to Function as a Pioneer Factor”的研究论文。...

FOXA1 （Forkhead box A1）的编码序列分别在高达9％的原发性前列腺癌和13％的mCRPC发生反复突变。 在另一种转移癌NEPC中，一项针对29个肿瘤组织的研究确定了 约25％的肿瘤存在定位于FOXA1的单核苷酸变异 （single nucleotide Variants, SNVs）。 最近一项数据表明，FOXA1的突变频率与种族背景相关。 对中国前列腺癌基因组和表观基因组图谱队列的分析显示，在41％的原发前列腺肿瘤中存在FOXA1突变，且这一比例显着高于西方人群。 尽管在整 …

叉头框蛋白A1 (forkhead-box A1, FOXA1)是叉头框(FOX)转录因子家族的成员。FOXA1主要是在胚胎产生、调控细胞的增殖与分化、人体器官生长发育及代谢调整等生理环节中发挥极为重要的调控功效。

It has been shown that FOXA1 is essential for AR-mediated prostatic gene activation, corroborated by the facts that FOXA1 regulatory elements are found in the core enhancer of the prostate-specific antigen (PSA) gene, a prototypical AR target, adjacent to the androgen response elements (AREs), and that perturbations in the FOXA1 motif can ...

FOXA1 (forkhead box A1), also known as HNF3 α (hepatocyte nuclear factor 3 α), is required for postnatal survival due to its essential role in controlling pancreatic and renal function.

2012年4月1日 · FOXA1 (forkhead box A1), also known as HNF3α (hepatocyte nuclear factor 3α), is required for postnatal survival due to its essential role in controlling pancreatic and renal function. In addition to regulating a variety of tissues during embryogenesis and early life, rescue experiments have revealed a specific role for FOXA1 in the postnatal ...

foxa1 概述. foxa1位于人类14q21.1染色体上，是一种由472个氨基酸组成的翼状螺旋转录因子，能够与非转录状态的染色体结合，同时提高其他转录起始因子的基因表达水平及转录效率，从而调节其下游基因的表达。