2024年12月25日 · FOXF1 (Forkhead Box F1) is a Protein Coding gene. Diseases associated with FOXF1 include Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins and Idiopathic/Heritable Pulmonary Arterial Hypertension. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

2023年5月4日 · We used transcriptional profiling of endothelial cells from human and mouse fibrotic lungs and identified FOXF1 as a critical transcriptional regulator of transition from normal to...

Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene. [5][6][7] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract. [8]

2024年6月19日 · Mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, a lethal lung disease...

The FOXF1 gene provides instructions for making the forkhead box F1 (FOXF1) protein. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes.

Multiple signaling pathways, structural proteins, and transcription factors are involved in the regulation of endothelial barrier function. The forkhead protein FOXF1 is a key transcriptional regul...

2014年9月26日 · FOXF1 is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling.

2024年5月6日 · 我们确定叉头盒f1（ foxf1 ）是ec到tec转变的关键调节因子。foxf1在正常肺血管中高表达，但在非小细胞肺癌(nsclc)的tec中表达降低。 FOXF1在正常肺血管中高表达，但在非小细胞肺癌(NSCLC)的TEC中表达降低。

FoxF1 was found to be a direct repressed target of NF1-C2; first evidence for a role of FoxF1 in cancer and regulation of EMT; overexpression associated with mesenchymal phenotype, increased invasiveness and enhanced growth of breast carcinoma xenografts

2018年6月14日 · Endothelial colony forming cells (ECFC) or late blood outgrowth endothelial cells (BOEC) have been proposed to contribute to neovascularization in humans. Exploring genes characteristic for the progenitor status of ECFC we have identified the forkhead box transcription factor FOXF1 to be selectively …