2024年12月25日 · FOXP1 (Forkhead Box P1) is a Protein Coding gene. Diseases associated with FOXP1 include Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features and Intellectual Disability …

Forkhead box protein P1 is a protein that in humans is encoded by the FOXP1 gene. FOXP1 is necessary for the proper development of the brain, heart, and lung in mammals. It is a member of the large FOX family of transcription factors.

2023年9月21日 · FOXP1 syndrome is caused by defects in FOXP1, which encodes FOXP1, part of the Forkhead box (FOX) group of proteins, an evolutionarily ancient family of transcription factors characterized by a highly conserved forkhead DNA-binding domain. FOXP1 has been associated with a wide range of functions including development of the brain, heart ...

2021年4月23日 · FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1) gene, which encodes a transcription factor important for the early development of many organ systems, including the brain.

2024年12月5日 · 该项研究鉴定了新的atr激活调控蛋白foxp1。 FOXP1通过与RPA-ssDNA直接结合募集到阻滞复制叉，并通过蛋白间直接互作促进ATR到染色质的募集以及ATR-CHK1通路的活化。

2019年1月14日 · Our studies suggest that Foxp1 serves an essential non-redundant function in T reg cells by enforcing Foxp3-mediated regulation of gene expression and enabling efficient IL-2 signaling in these...

2024年5月3日 · We find a neuron subtype-specific role of FOXP1 in strengthening and maturing glutamatergic inputs onto dopamine receptor 2–expressing SPNs (D2 SPNs). We also find that FOXP1 promotes synaptically driven excitability in these neurons.

叉头框蛋白p1(Foxp1)是一种属于叉头框(Forkhead box, Fox)转录因子家族的转录因子,Foxp1最早克隆于小鼠B细胞白血病细胞系,较早的研究表明Foxp1对生物体器官包括心脏和肺的正常发育起着重要的调控作用,且在多种人类肿瘤中异常表达而抑制或促进肿瘤发生发展.最近越来 ...

FOXP1 syndrome is characterized by delays in early motor and language milestones, mild-to-severe intellectual deficits, speech and language impairment in all individuals regardless of level of cognitive abilities, and behavior abnormalities (including autism spectrum disorder or autistic features, attention-deficit/hyperactivity disorder ...

FOXP1 syndrome is a rare genetic disorder characterized by delays in early motor and language milestones, mild-to-severe intellectual deficits, speech and language impairment and behavior abnormalities.