In a systematic literature review published in the Journal of Thrombosis and Haemostasis, Chatree Chai-Adisaksopha, PhD, of the Department of Medicine at McMaster University in Canada, and authors analyzed 13 studies investigating the efficacy and safety of PCCs or FFP for warfarin reversal, finding that reversal with PCC was associated with a ...

2016年10月28日 · Urgent reversal of warfarin is required for patients who experience major bleeding or require urgent surgery. Treatment options include the combination of vitamin K and coagulation factor replacement with either prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP). However, the optimal …

Fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC) reverse oral anticoagulants such as Warfarin. We compared the standard dosage of FFP and PCC in terms of efficacy and safety for patients with mechanical heart valves undergoing ...

This study suggests that, for patients who experience excessive bleeding during cardiac surgery and require coagulation factor replacement as part of routine clinical care, PCC may be a suitable substitute for FP—only 2 patients who were randomized to PCC required FP in addition to PCC, albeit with a wide 95% CI of 0.4% to 12.7% around the 3. ...

We compared PCC and FFP intraoperative administration in patients undergoing heart surgery with cardiopulmonary bypass (CPB). Methods: Forty patients [with international normalized ratio (INR)≥ 2·1] assigned semi-urgent cardiac surgery were randomized to receive either FFP (n = 20) or PCC (n = 20).

PCC in conjunction with FFP rapidly corrects INR in a matched cohort of trauma patients not on warfarin therapy compared with FFP therapy alone. The use of PCC as an adjunct to FFP therapy is associated with reduction of blood product requirement and also lowers overall cost.

We assessed the safety and efficacy of fresh frozen plasma (FFP) versus prothrombin complex concentrate (PCC) in patients with VKA-ICH. We did an investigator-initiated, multicentre, prospective, randomised, open-label, blinded-endpoint trial.

2020年12月7日 · A recent multinational observational study that compared clinical outcomes of bleeding patients who received PCC compared with FFP showed that the PCC cohort received significantly more fibrinogen concentrate (43% vs.15%) and cryoprecipitate (3.4% vs. 0.5%) than FFP patients, but not red cell transfusions .

Compared with fresh frozen plasma (FFP), prothrombin complex concentrate (PCC) may potentially offer a more rapid and effective means of normalizing coagulation factor levels. In anaesthetized mildly hypothermic pigs, 65–70% of total blood volume was substituted in phases with hydroxyethyl starch and red cells.

Prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP) are commonly used to manage bleeding in patients during cardiac surgery. However, the relative efficacy and safety of these 2 strategies remain uncertain.