Our results suggest that FSH phosphorylates CREB, promoting its binding to the Mdh2 promoter and enhancing its transcription. The newly identified FSH-CREB-MDH2 axis may be critical for regulating osteoclast metabolism and activity.

2023年2月25日 · We uncover paracrine FSH action on pituitary corticotropes as a mechanism to restrain the production of corticosterone and prevent hepatic steatosis. Our data demonstrate that functional...

This study reveals the effects of follicle-stimulating hormone (FSH) on osteoclast energy metabolism. Methods: The Lyz2-Cre-Flox model selectively deletes FSH receptor (FSHR) from osteoclast precursor cells to generate Fshr f/f; Lyz2-Cre (Fshr f/f; Cre) mice. Bone quality was assessed using micro-computed tomography, histomorphometric analysis ...

2023年11月4日 · FSH结合并激活FSH受体（FSHR）发挥生物学效应，FSHR属于七重跨膜G蛋白偶联受体（GPCR）家族，敲除小鼠FSH β亚基或FSHR基因导致显著的生殖障碍。 传统观念认为，FSH仅是一种重要的生殖激素。 但近10年对FSH及其受体深入研究发现，FSHR在性腺外组织如破骨细胞、脂肪细胞和神经细胞均表达，FSH通过FSHR起到调节骨量、脂质代谢和调控认知功能等。 值得关注的是，大量流行病学研究表明，围绝经期和绝经后女性发生糖尿病、代谢综合 …

We have reported that gestational exposure to hexavalent chromium (CrVI) represses androgen receptor (Ar) and follicle stimulating hormone receptor (Fshr) in Sertoli cells (SCs) of adult rats,...

2021年12月2日 · Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than the fully-glycosylated variant (FSH24).

2018年12月17日 · In this study, we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis. First, epidemiological results show that the serum FSH levels are positively...

2023年1月31日 · Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human reproduction, which functions are mediated by a G protein-coupled receptor, FSHR....

The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH.

1995年11月11日 · Here we show that ICER represses FSH receptor expression by binding to a CRE-like sequence in the regulatory region of the gene. Our results confirm the crucial role played by CREM in hormonal control and suggest its role in the long-term desensitization phenomenon of peptide membrane receptors.