SAMD1 has an atypical winged-helix domain that directly recognizes unmethylated CpG-containing DNA via simultaneous interactions with both the major and the minor groove. The SAM domain interacts with L3MBTL3, but it can also homopolymerize into a closed pentameric ring.

2024年11月5日 · Since SAMD1 is highly expressed in HSPCs, interacts with and controls the function of known epigenetic writer proteins, and our data predicts that SAMD1 may control the expression of hematopoietic transcription factors (e.g., GATA2), we hypothesize that SAMD1 coordinates H3K4 methylation to control hematopoiesis.

2024年8月1日 · The sterile alpha motif-containing 1 (SAMD1) gene encodes a transcription factor which coordinates histone modifications during embryonic stem cell exit from pluripotency. SAMD1 is expressed throughout many biological systems, but …

Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix domain that directly recognizes unmethylated CpG-containing DNA via simultaneous interactions with both the major and the minor groove.

fbxo11 在其 dna 结合翼状螺旋结构域内泛素化 samd1，并在全基因组范围内抑制 samd1 染色质结合。 PDAC 中 FBXO11 高表达与预后不良和 EMT 相关基因表达增加相关，强调了 SAMD1 和 FBXO11 之间的拮抗关系。

2021年5月13日，德国马尔堡大学的Robert Liefke实验室与王占新实验室继续合作，在Science Advances在线发表题为The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands 的文章，发现SAMD1是一个新的CpG岛调控因子，通过其非典型WH结构域招募 ...

2024年11月5日 · SAMD1 knockout is embryonic lethal, and no conditional knockout mouse currently exists. To clarify the role of SAMD1 in hematopoiesis, we conducted competitive transplant experiments in mice using shRNA knockdown HSCs. Samd1 knockdown versus control HSCs revealed an increase in HSC repopulation with 2.7-fold more CD45.2 + after 16 weeks ...

2024年12月25日 · SAMD1 (Sterile Alpha Motif Domain Containing 1) is a Protein Coding gene. Diseases associated with SAMD1 include Essential Tremor 6 and Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language .

2021年5月1日 · Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix domain that directly recognizes...

2021年5月12日 · Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix domain that directly recognizes unmethylated CpG-containing DNA via simultaneous interactions with both the major and the minor groove.