FSL-1 is a synthetic diacylated lipoprotein that activates the TLR2/TLR6 heterodimer. InvivoGen FSL-1 is cell culture-tested to guarantee specific activation of the TLR2 pathway and the …

FSL-1 can be used to activate TLR2 in HEK-BlueTM TLR2 cells that were designed to study TLR2 stimulation by monitoring NF-κB activation. Stimulation of HEK-BlueTM TLR2 cells with a …

2017年12月11日 · We demonstrate that the synthetic TLR2/6 ligand Fibroblast–stimulating lipopeptide (FSL–1) substantially prolongs survival in both male and female mice when …

FSL-1 lipoprotein, synthetic | C84H140N14O18S | CID 87858248 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

2009年11月10日 · FSL-1 was tested at several doses and application times in the mouse model and in human vaginal EC cultures to evaluate potential induced resistance to genital HSV-2 …

2024年12月30日 · We selected FSL-1, a synthetic diacyl lipopeptide recognized by Toll-like receptor 2/6 (TLR2/6) heterodimers, to mimic bacterial infections. In addition, we attempted to …

2024年5月1日 · Here we report on the efficacious nature of FSL-1 (toll-like receptor 2/6 agonist) and the protection from acute radiation syndrome (ARS) in a murine total-body irradiation (TBI) …

FSL-1 increases IgE and IgA responses to foods during systemic antigenic challenge. In vitro, this compound increases expression and activity of MMP-9, IL-6, IL-9, and COX-2. FSL-1 is also …

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N …

FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6). 1, 2 In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 …

We identify the TLR2/6 ligand FSL–1 as a potent radiomitigator that was superior to all others we tested, demonstrating exceptional efficacy and diminished adverse effects. We present data …

2017年12月11日 · We demonstrate that the synthetic TLR2/6 ligand Fibroblast-stimulating lipopeptide (FSL-1) substantially prolongs survival in both male and female mice when …

2009年11月10日 · The results showed, for the first time, that the bacterial-derived TLR2/6 agonist FSL-1 induced significant resistance to HSV-2 infection when applied in mice or human …

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein derived from Mycoplasma salivarium. This mycoplasmal lipoprotein contains a diacylated cysteine residue and is recognized by the …

Fibroblast-stimulating lipopeptide (FSL-1) can activate Toll-like receptor 2 and 6 (TLR2/6), which recognize relevant molecules from gram-positive pathogens, fungus, and mycoplasma, and …

FSL-1 Non- Endotoxin Pyrogen (NEP) Control activates TLR2/TLR6 receptor of monocytes and is used as a positive control for PyroMAT ® system. The response to pyrogenic substances is …

2014年12月30日 · We selected FSL-1, a synthetic diacyl lipopeptide recognized by Toll-like receptor 2/6 (TLR2/6) heterodimers, to mimic bacterial infections. In addition, we attempted to …

2009年11月10日 · The results showed that vaginally-applied FSL-1 created an environment resistant to a 25-fold higher HSV-2 challenge dose. Mechanistically, vaginal FSL-1 application …

We demonstrate that life-threatening hematopoietic injuries in mice and nonhuman primates due to radiation are mitigated with a single subcutaneous administration of the TLR2/TLR6 ligand …