FSL-1 is a synthetic diacylated lipoprotein that activates the TLR2/TLR6 heterodimer. InvivoGen FSL-1 is cell culture-tested to guarantee specific activation of the TLR2 pathway and the absence of interference by any endotoxin contaminants.

FSL-1 can be used to activate TLR2 in HEK-BlueTM TLR2 cells that were designed to study TLR2 stimulation by monitoring NF-κB activation. Stimulation of HEK-BlueTM TLR2 cells with a TLR2 agonist activates NF-κB which induces the production of …

Dec 11, 2017 · We demonstrate that the synthetic TLR2/6 ligand Fibroblast–stimulating lipopeptide (FSL–1) substantially prolongs survival in both male and female mice when administered 24 hours...

FSL-1 lipoprotein, synthetic | C84H140N14O18S | CID 87858248 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Nov 10, 2009 · FSL-1 was tested at several doses and application times in the mouse model and in human vaginal EC cultures to evaluate potential induced resistance to genital HSV-2 infection.

Dec 30, 2024 · We selected FSL-1, a synthetic diacyl lipopeptide recognized by Toll-like receptor 2/6 (TLR2/6) heterodimers, to mimic bacterial infections. In addition, we attempted to identify cellular signaling molecules involved in production of IL-1α in order to elucidate molecular mechanisms underlying TLR6-mediated expression of inflammatory cytokines.

May 1, 2024 · Here we report on the efficacious nature of FSL-1 (toll-like receptor 2/6 agonist) and the protection from acute radiation syndrome (ARS) in a murine total-body irradiation (TBI) model. A single dose of FSL-1 was administered subcutaneously in mice.

FSL-1 increases IgE and IgA responses to foods during systemic antigenic challenge. In vitro, this compound increases expression and activity of MMP-9, IL-6, IL-9, and COX-2. FSL-1 is also used as an adjuvant, in which it induces a Th2-specific response by increasing IgA and IgG levels.

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium.

FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6). 1, 2 In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-κB activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively. 1 It induces the expression of the cytokines CCL20 ...

We identify the TLR2/6 ligand FSL–1 as a potent radiomitigator that was superior to all others we tested, demonstrating exceptional efficacy and diminished adverse effects. We present data showing that the radiomitigation activity of FSL–1 is sex–independent and MyD88–dependent.

Dec 11, 2017 · We demonstrate that the synthetic TLR2/6 ligand Fibroblast-stimulating lipopeptide (FSL-1) substantially prolongs survival in both male and female mice when administered 24 hours after radiation and shows MyD88-dependent function.

Nov 10, 2009 · The results showed, for the first time, that the bacterial-derived TLR2/6 agonist FSL-1 induced significant resistance to HSV-2 infection when applied in mice or human vaginal EC cultures.

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein derived from Mycoplasma salivarium. This mycoplasmal lipoprotein contains a diacylated cysteine residue and is recognized by the TLR2/TLR6 heterodimer.

Fibroblast-stimulating lipopeptide (FSL-1) can activate Toll-like receptor 2 and 6 (TLR2/6), which recognize relevant molecules from gram-positive pathogens, fungus, and mycoplasma, and elevates the expression of CXCL1 and CXCL2, neutrophil chemoattractants, in …

FSL-1 Non- Endotoxin Pyrogen (NEP) Control activates TLR2/TLR6 receptor of monocytes and is used as a positive control for PyroMAT ® system. The response to pyrogenic substances is determined by measuring the Interleukin-6 (IL-6) produced by …

Dec 30, 2014 · We selected FSL-1, a synthetic diacyl lipopeptide recognized by Toll-like receptor 2/6 (TLR2/6) heterodimers, to mimic bacterial infections. In addition, we attempted to identify cellular signaling molecules involved in production of IL-1α in order to elucidate molecular mechanisms underlying TLR6-mediated expression of inflammatory cytokines.

Nov 10, 2009 · The results showed that vaginally-applied FSL-1 created an environment resistant to a 25-fold higher HSV-2 challenge dose. Mechanistically, vaginal FSL-1 application led to transient elaboration of cytokines linked to anti-herpetic innate immune responses.

We demonstrate that life-threatening hematopoietic injuries in mice and nonhuman primates due to radiation are mitigated with a single subcutaneous administration of the TLR2/TLR6 ligand FSL-1. In mice, bone marrow progenitors are significantly enhanced with FSL …