2024年12月25日 · FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia and Tremor, Hereditary Essential, 4. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and MECP2 and associated Rett syndrome.

Franklin University Switzerland is a four-year American university in Lugano, Switzerland for students who want an English language education in Europe.

2023年12月19日 · 功能超声成像（fUS)是小动物脑功成像领域突破性的新技术，具有优于传统技术的敏感性和空间分辨率，而其最大优势是具有非常好的轻便性。 不同于传统技术，如小动物fMRI多应用于麻醉的动物，fUS非常适合于在清醒甚至活动的动物上进行成像。

2020年8月27日 · fUS（functional ultrasound）是一种全新的脑功能成像技术，具有比fMRI更高的空间分辨率和信噪比，另外突破性的超小探头适合于自由活动动物的检测。 因此，相比fMRI更加适合实验动物的脑功能检测，已经有很多研究利用fUS技术来检测动物行为或刺激相关的脑活动 ...

Autosomal dominant mutations in the gene encoding the DNA and RNA binding protein FUS are a cause of amyotrophic lateral sclerosis (ALS), and about 0·3-0·9% of patients with ALS are FUS mutation carriers. FUS-mutation-associated ALS (FUS-ALS) is characterised by early onset and rapid progression, co …

The FUS gene provides instructions for making a protein that is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The FUS protein attaches (binds) to DNA and regulates an activity called transcription, which is the first step in the production of proteins from genes.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic mislocalization cause a subset of ALS. Under stress, mutant FUS localizes to stress granules (SGs)—cytoplasmic condensates composed of RNA and various proteins.

2021年5月21日 · Our study indicates that synaptic FUS accumulation in early disease leads to synaptic impairment, potentially representing an initial trigger of neurodegeneration. Fused in sarcoma (FUS) is a...

2024年2月1日 · Fused in sarcoma (FUS) is an archetypal phase separating protein asymmetrically divided into a low complexity domain (LCD) and an RNA binding domain (RBD). Here, we explore how the two domains contribute to RNA-dependent phase separation, RNA recognition, and multivalent complex formation.

2019年4月24日 · Fused in sarcoma (FUS) is a DNA/RNA binding protein containing 526 amino acids. The FUS gene was initially identified as a fusion oncogene on chromosome 16 in human liposarcoma [1], the translocation and fusion of which to transcription factors results in strong transcriptional activation of the proteins.