2018年9月24日 · Our biochemical and genetic experiments demonstrate that FUS interacts with the catalytic subunit of mitochondrial ATP synthase (ATP5B), disrupts the formation of ATP synthase complexes, and inhibits mitochondrial ATP synthesis. FUS expression activates the mitochondrial unfolded protein response (UPR mt).

2019年6月20日 · Kang et al investigate by NMR and modeling methods how ATP influences the neurodegeneration–associated protein FUS. They find that ATP binds the RNA-binding RRM domain of FUS and inhibits...

Our biochemical and genetic experiments demonstrate that FUS interacts with the catalytic subunit of mitochondrial ATP synthase (ATP5B), disrupts the formation of ATP synthase complexes, and inhibits mitochondrial ATP synthesis. FUS expression activates the mitochondrial unfolded protein response (UPR mt).

2022年9月14日 · Here, taking the fused in sarcoma (FUS) solution as an example, we comprehensively reveal the underlying mechanism by which ATP regulates phase separation by combining the semiempirical quantum mechanical method, mean …

2019年6月20日 · Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence motif and thereby affects FUS liquid-liquid phase separation.

在这里，我们以融合肉瘤 (fus) 溶液为例，结合半经验量子力学方法、平均场理论和分子模拟，全面揭示了 atp 调节相分离的潜在机制。 在微观层面，ATP 充当二价或三价结合剂；在宏观层面上，重入相分离发生在稀释的 FUS 溶液中，这是由不同条件下 ATP 浓度依赖 ...

2025年1月31日 · Here, we used all-atom molecular dynamics simulation to study the interaction of ATP with two typical IDPs (i.e., FUS PLD and RGG domain of hnRNP G), and its impacts on IDP interactions. ATP exhibits a considerable tendency to bind to both IDPs and effectively inhibits their interactions.

2018年9月26日 · fus靶向线粒体atp合成从而激活uprmt的研究结果，揭示了fus诱导神经退行性疾病的新机制，提示线粒体损伤可能是ftld-fus和als-fus等多种神经退行性疾病的共有机制，阻断线粒体损伤可能有助于治疗这些毁灭性疾病。

2017年5月19日 · To investigate this phenomenon further, we tested the effect of ATP on the formation of liquid compartments formed by purified fused in sarcoma (FUS). In healthy cells, FUS forms liquid compartments that are involved in transcription, DNA repair, and RNA biogenesis (4 – …

2018年9月27日 · fus靶向线粒体atp合成从而激活uprmt的研究结果，揭示了fus诱导神经退行性疾病的新机制，提示线粒体损伤可能是ftld-fus和als-fus等多种神经退行性疾病的共有机制，阻断线粒体损伤可能有助于治疗这些毁灭性疾病。