Alpha- (1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene. [5][6] This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides.

2024年12月25日 · FUT8 (Fucosyltransferase 8) is a Protein Coding gene. Diseases associated with FUT8 include Congenital Disorder Of Glycosylation With Defective Fucosylation 1 and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are Translation of Structural Proteins and Infectious disease.

Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for this modification via the addition of L-fucose residue from guanosine diphosphate-β-L-fucose. The crystal structure of human FUT8 provided insight into both catalytic mechanism and substrate recognition.

2020年2月20日 · Here, we report the crystal structure of FUT8 complexed with GDP and a biantennary complex N -glycan (G0), which provides insight into both substrate recognition and catalysis. FUT8 follows an...

2023年8月10日 · 该研究发现，核心岩藻糖基转移酶8（FUT8）靶向抑制剂FDW028（中国授权专利：ZL202210012997.7）能够显著抑制FUT8介导的核心岩藻糖修饰，促进免疫检查点分子B7-H3经分子伴侣介导的自噬（CMA）溶酶体途径降解，显著延长转移性结直肠癌（mCRC）小鼠生 …

2021年12月2日 · Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for core fucosylation, and aberrant fucosylation by dysregulated expression of fucosyltransferases is...

2025年2月1日 · Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections.

2024年9月18日 · FUT8（Fucosyltransferase 8）是α1,6-岩藻糖基转移酶家族中的一种关键酶，主要. 参与糖蛋白核心岩藻糖基化的过程。 它在多种生物过程中扮演重要角色，如细胞信. 号传导、细胞粘附、免疫调节等。 FUT8对糖蛋白的岩藻糖基化修饰在细胞外基. 质、细胞侵袭、器官发育等方面具有关键功能。 以下是FUT8蛋白的功能和结构特. 性详细解述： 1. FUT8的结构特性. 目录号 PA1000-6569. 1.1 蛋白的总体结构. FUT8是一种约50 kDa的糖基转移酶，属于第八类岩藻糖基 …

2021年1月5日 · Core fucosylation is driven by fucosyltransferase 8 (FUT8), which catalyses the addition of α1,6-fucose to the innermost GlcNAc residue of N-glycans. FUT8 is frequently upregulated in cancer, and plays a critical role in immune evasion, antibody-dependent cellular cytotoxicity (ADCC), and the regulation of TGF-β, EGF, α3β1 integrin and E ...

2025年1月4日 · Gene target information for FUT8 - fucosyltransferase 8 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.