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PXR、CAR和VDR是密切相关的核受体，在BA解毒和清除过程中发挥相似的作用。 虽然CAR没有任何已知的BA配体，但这三种核受体都能促进肝毒性LCA 的清除。

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胆汁酸 除调节自身合成外， 还通过与FXR，TGR5， PXR， VDR 和 CAR 等胆汁酸受体结合，发挥影响代谢和免疫作用。 激动剂刺激胆汁酸受体FXR可发挥抗炎作用，在化学诱导的 结肠炎 中具有保护作用。

法尼醇X受体（Farnesoid X Receptor，FXR）是核受体（nuclear receptor，NR）超家族的成员，属于亚家族（Subfamily）1、组（Group）H、成员（Member）4，因此可称为NR1H4，在人类由核受体基因NR1H4编码。

2022年1月28日 · FXR（法尼醇X受体）是近几年来非酒精性脂肪性肝病（NAFLD）研究的一个热门靶点。 FXR是核受体超家族的成员之一，该受体于1995年由Forman等发现，因其转录活性可被法尼醇及其代谢物增强而命名，后研究发现胆汁酸是FXR的内源性配体，因此FXR又称胆汁酸受体。 FXR在哺乳动物中有两个成员：FXRα和FXRβ。 FXRβ在人类和灵长类动物中是一种假基因，但在其他物种中编码一种功能性受体。 FXRα基因编码四种亚型：FXRα1-α4，这四种亚型以组 …

2021年6月1日 · PXR and CAR are xenobiotic receptors that regulate the expression of drug-metabolizing enzymes and transporters. PXR and CAR have equally important roles in governing the homeostasis of numerous endobiotics. PXR and CAR have overlapping yet distinct functions in liver physiology and pathophysiology.

To characterize human nuclear receptor (NR) specificity of synthetic pharmaceutical chemicals we established stable cell lines expressing the ligand binding domains (LBDs) of human FXR, LXRα, LXRβ, CAR, and RORγ fused to the yeast GAL4 DNA binding ...

2011年3月1日 · This review will discuss the evolution of two NHR subfamilies, NR1H and NR1I, that include liver X receptors (LXRs) α and β (NR1H3 and 1H2, respectively), farnesoid X receptor (FXR, NR1H4), vitamin D receptor (VDR, NR1I1), PXR (NR1I2), and CAR (NR1I3).

2011年3月1日 · Some of these receptors, particularly PXR and CAR, are promiscuous with respect to the structurally wide range of ligands that act as agonists. A combination of functional and computational analyses has shed light on the evolutionary changes of NR1H and NR1I receptors across vertebrates, and how these receptors may have diverged from ancestral ...