Bile acids act on FXR in ileal enterocytes to induce the expression of fibroblast growth factor (FGF)15/19, an atypical FGF that functions as a hormone. FGF15/19 subsequently acts on a cell surface receptor complex in hepatocytes to repress bile acid synthesis and gluconeogenesis, and to stimulate glycogen and protein synthesis.

FXR通过结合SHP基因启动子区域的FXR结合位点(FXR Response Element, FXRRE),又称IR1序列,以调控SHP基因的转录表达，进而维持肝脏胆汁合成与代谢稳态。 作为FXR最主要的下游基因，SHP与肝脏肿瘤形成关系密切。

2021年9月1日 · We review the roles of FXR and one of its intestinal target genes, fibroblast growth factor (FGF) 15 in mice/FGF19 in humans, play in regulating these important pathways in health and diseases.

2024年10月10日 · We identified hepatic Fgf4 as a direct FXR target that paracrinally signals to downregulate Cyp7a1 and Cyp8b1. The effect of FXR-FGF4 is mediated by an uncharted intracellular FGF receptor 4 (FGFR4)-LRH-1 signaling node.

fxr 刺激fgf19/15 在小肠中表达，后者通过靶向FGFR4 和孤核受体小异源二聚体伴侣(SHP)抑制肝脏中的胆固醇7α-羟化酶 (CYP7A1)活性和表达，该酶负责催化经典胆汁酸合成途径中的第一步和限速步骤。

2024年11月26日 · fxr是ba稳态的中心调控因子，目前已知的一个通路是fxr通过激活小鼠肠道fgf15（人是fgf19）的转录来发挥调控作用。 作为一种肠源性激素，FGF15由肠道细胞分泌后作用于肝细胞的FGFR4，进而抑制Cyp7a1和Cyp8b1的表达，从而调节餐后BA稳态。

2010年6月7日 · Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which the bile acid-activated nuclear receptor farnesoid X receptor (FXR) in liver and intestine-derived,...

The bile acid (BA)-sensing nuclear receptor, farnesoid X receptor (FXR), regulates postprandial metabolic responses, including inhibition of BA synthesis, by inducing the intestinal hormone, fibroblast growth factor (FGF)15 (FGF19 in human). In this study, we tested a novel hypothesis that FXR not o …

2021年10月11日 · 在肠道中，FXR的激活会导致成纤维细胞生长因子(Fibroblast growth factor，FGF)19的表达，其进入肝脏中激活FGF受体4(FGFR4)并最终抑制CYP7A1的表达，从而抑制胆汁酸的合成。

2022年5月27日 · Farnesoid X receptor (FXR) is a nuclear receptor that forms a heterodimer with retinoid X receptor α (RXRα), is activated by BAs in the enterohepatic circulation reabsorbed via transporters in the ileum and the colon, and plays a critical role in regulating gene expression involved in cholesterol, BA, and lipid metabolism in the liver.