Farnesoid X receptor overexpression prevents hepatic steatosis …
2024年2月1日 · FXR alleviates oxidative stress and ROS production in palmitic acid-induced hepatic steatosis. Oxidative stress-mediated activation of inflammasome has a significant effect on the pathogenesis of nonalcoholic fatty liver disease (NAFLD).
The critical role of FXR is associated with the regulation of …
2021年3月25日 · Here, using farnesoid X receptor (FXR) knockout (KO) mice, we determined whether FXR prevents the progression of AKI to CKD after renal ischemic-reperfusion (such as I/R) injury through the...
Role of farnesoid X receptor in hepatic steatosis in nonalcoholic …
2020年1月1日 · FXR is a ligand-activated nuclear receptor that plays an important role in regulating lipid metabolism. FXR activation represses hepatic lipogenesis via the FXR-SHP-SREBP-1c pathway. FXR activation promotes FA oxidation by stimulating the expressions of PPARα and CPT1. FXR activation reduces hepatic FA uptake via reduction of CD36.
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in
2024年1月18日 · FXR1 knockdown increased ROS generation and ROS-FXR1-TGF-b-mediated epirubicin sensitivity. siFXR1’s galectin-3/b-catenin signaling suppression inhibited MDR protein expression in colorectal ...
FXR activation suppresses ROS production. A, ROS levels in FXR ...
In the present work, we identify a novel role of FXR in antagonizing c-Jun N-terminal kinase (JNK) signaling pathway in liver carcinogenesis by activating SOD3 transcription.
The role of the farnesoid X receptor in kidney health and disease: a ...
2023年2月3日 · FXR activation by agonists has kidney-protective effects against fibrosis, inflammation, apoptosis, ferroptosis, and ROS accumulation and plays roles in lipid and glucose metabolism.
FXR overexpression prevents hepatic steatosis through inhibiting …
2024年1月6日 · DCFH–DA staining was adopted to visualize reactive oxidative species (ROS). FXR was distinctly downregulated in liver tissues of patients with steatosis compared to normal livers using the GEO database, and in ethanol-induced AML-12 cellular steatosis model.
Farnesoid X receptor (FXR) agonists induce hepatocellular …
Farnesoid X receptor (FXR) plays an indispensable role in liver homeostasis and has been a promising drug target for hepatic diseases. However, the concerns of undesired biological actions limit the clinical applications of FXR agonists. To reveal the intrinsic mechanism of FXR agonist-induce hepato …
Cell Metabolism | FXR激活可通过胆汁酸依赖方式降低脂质吸收从 …
目前，NALFD/NASH患者的治疗方案非常有限，不过 核受体 法尼醇X受体 (FXR) 激动剂已显示出较好的应用前景。 已有研究表明，FXR激活与肝脏和血浆 甘油三酯 （TAG）水平降低、炎症减轻、 胰岛素敏感性 增加等多种临床变化相关。
NASH等代谢疾病热门靶点——FXR受体，激动 or 拮抗 - 脉脉
2022年1月28日 · FXR（法尼醇X受体）是近几年来非酒精性脂肪性肝病（NAFLD）研究的一个热门靶点。 FXR是核受体超家族的成员之一，该受体于1995年由Forman等发现，因其转录活性可被法尼醇及其代谢物增强而命名，后研究发现胆汁酸是FXR的内源性配体，因此FXR又称胆汁酸受体。 FXR在哺乳动物中有两个成员：FXRα和FXRβ。 FXRβ在人类和灵长类动物中是一种假基因，但在其他物种中编码一种功能性受体。 FXRα基因编码四种亚型：FXRα1-α4，这四种亚型以组 …