2024年12月25日 · FXR2 (FMR1 Autosomal Homolog 2) is a Protein Coding gene. Diseases associated with FXR2 include Fragile X Syndrome and X-Linked Hereditary Ataxia. Among its related pathways are VEGFA-VEGFR2 signaling and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding.

The fragile X-related (FXR) family proteins FMRP, FXR1, and FXR2 are RNA binding proteins that play a critical role in RNA metabolism, neuronal plasticity, and muscle development. These proteins share significant homology in their protein domains, which are functionally and structurally similar to e …

2025年3月1日 · Results: FXR2 protein expression was significantly associated with human epidermal growth factor 2 (HER2) negativity (p = 0.010) and low Ki67 (p < 0.001). Both DNA microarray and RNA sequence data showed that HER2 negativity was strongly linked to high levels of FXR2 mRNA.

2015年6月16日 · FMRP and FXR2P additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GluA1, but they do so via distinct mechanisms: FXR2P binds and stabilizes GluA1 mRNA and enhances subsequent protein expression, whereas FMRP promotes GluA1 membrane delivery.

One cDNA clone was identified that encodes a novel protein termed here FXR2. Surprisingly, FXR2 has extensive sequence similarity with FMR1 and with the recently described autosomal homolog FXR1 (Siomi et al., 1995). Here we report these findings and demonstrate that FXR1 also interacts with FMR1 and with FXR2.

该基因编码的蛋白是一种含有两个 KH 结构域和一个 RCG 盒的 RNA 结合蛋白，与 FMRP 和 FXR1 相似。 它与多聚核糖体结合，主要与 60S 大核糖体亚基结合。 这种编码的蛋白质可能与 FMRP 和 FXR1 自我结合或相互作用。 它可能在脆性 X 认知障碍综合征的发展中起作用。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1.

FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits.

2022年12月20日 · The pleiotropic actions of the Farnesoid X Receptor (FXR) are required for gut health, and reciprocally, reduced intestinal FXR signaling is seen in inflammatory bowel diseases (IBDs). Here, we show that activation of FXR selectively in the intestine is protective in inflammation-driven models of IB …

FXR2 Antibody detects endogenous levels of total FXR2 protein. Human, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human FXR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

FXR2的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质是含有两个KH域和一个RCG盒，其类似于FMRP和FXR1一个RNA结合蛋白。 它与关联多核糖体，主要与大60S核糖体亚基。 该编码蛋白可以自结合或FMRP与FXR1相互作用。 它可以具有脆性X智力低下综合症的发展中的作用。 [由RefSeq的，2008年7月提供]