FORCE platform overcomes barriers of oligonucleotide delivery
2025年1月18日 · We developed the FORCE TM platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. …
Comparing in vitro affinity measurements of antibodies to TfR1: …
2024年3月1日 · Transferrin receptor 1 (TfR1) is an especially popular target for this molecular Trojan horse strategy. TfR1 forms a homodimer consisting of two subunits which bind to holo …
分子生物 | Nature | 转铁蛋白受体靶向嵌合体用于膜蛋白降解 - 知乎
癌细胞为了快速增殖需要高水平的铁，导致细胞表面转铁蛋白受体1（TfR1）显著上调，该受体通过与携带铁的蛋白质转铁蛋白结合来介导铁的摄取1,2,3。 利用这一现象以及TfR1的快速内吞 …
Transferrin receptor-binding blood-brain barrier shuttle ... - bioRxiv
2025年2月16日 · Transferrin receptor-1 (TfR1) transcytosis-mediated delivery of therapeutic monoclonal antibodies across the blood-brain barrier (BBB) is a promising concept in drug …
3. TFR1在肿瘤、神经退行性等疾病中的作用 - 华美生物
2024年10月23日 · 这一研究于2024年9月25日发表在Nature上，TransTAC代表了一类有前景的新型双功能抗体家族，可用于精确调控膜蛋白和靶向癌症治疗。 现有研究证实，TFR1在许多肿 …
Targeted tissue delivery of RNA therapeutics using antibody ...
2023年5月24日 · Sugo et al. described the utility of targeting the transferrin receptor 1 (TfR1) to deliver oligonucleotides to skeletal muscle and heart tissue. They demonstrated in rodents a …
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as ... - PubMed
2021年3月17日 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a …
Antibody–oligonucleotide conjugates enter the clinic - Nature
2021年12月13日 · Her team attached various siRNA payloads to an antigen-binding fragment (Fab) that engaged the HIV-1 envelope protein. As a linker they used protamine, a protein that …
Drugs catch a ride through the blood–brain barrier - Nature
2023年9月12日 · At this year’s annual meeting of the American Society of Gene & Cell Therapy, Dyne Therapeutics described a monovalent Fab antibody variable region fragment with high …
Targeting the transferrin receptor to transport antisense ...
2024年8月14日 · Here, we engineered a human transferrin receptor 1 (TfR1) binding molecule, the oligonucleotide transport vehicle (OTV), to transport a tool ASO across the BBB in human …
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