Discovery of Natural FabH Inhibitors Using an Immobilized …
β-Ketoacyl-acyl carrier protein synthase III (KAS III, FabH) is essential for bacterial fatty acid biosynthesis. Recent studies indicate that FabH can be a potential target for bactericide …
The Molecular Basis of the β-Ketoacyl-ACP Synthase FabH in …
2025年3月10日 · β-Ketoacyl-ACP synthases (KAS) catalyze carbon skeleton extension in numerous metabolic routes such as the fatty acid biosynthesis pathway (FAS), among which …
Refined structures of β-ketoacyl-acyl carrier protein synthase III
2001年3月16日 · β-Ketoacyl-acyl carrier protein synthase III (FabH) is a condensing enzyme that plays central roles in fatty acid biosynthesis. Three-dimensional structures of E. coli FabH in …
β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is Essential …
2003年12月19日 · β-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first …
Activity of Fatty Acid Biosynthesis Initiating Ketosynthase FabH …
2023年1月10日 · FabH performs an acyltransferase reaction with acetyl-CoA to generate an acetyl-S-FabH acyl-enzyme intermediate and subsequent decarboxylative Claisen …
3-Ketoacyl-ACP synthase III FabH1 is essential for branched-chain …
2023年6月13日 · The 3-ketoacyl-ACP synthase III (FabH), a key enzyme for bacteria growth, catalyses the last step of the initiation of bacterial fatty acid synthesis. Rice bacterial blight is …
Crystal Structure of β-Ketoacyl-Acyl Carrier Protein Synthase III: …
1999年12月17日 · β-Ketoacyl-acyl carrier protein synthase III (FabH), the most divergent member of the family of condensing enzymes, is a key catalyst in bacterial fatty acid biosynthesis and a …
Beta-ketoacyl-acyl carrier protein synthase III (FabH) is ... - PubMed
2003年12月19日 · beta-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first …
Inhibition of β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) by ...
β-Ketoacyl-acyl carrier protein (ACP) synthase III (the fabH gene product) condenses acetyl-CoA with malonyl-ACP to initiate fatty acid biosynthesis in the dissociated, type II fatty acid …
Crystal structure and substrate specificity of the beta-ketoacyl-acyl ...
beta-Ketoacyl-ACP synthase III (FabH), an essential enzyme for bacterial viability, catalyzes the initiation of fatty acid elongation by condensing malonyl-ACP with acetyl-CoA. We have …
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