β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is Essential …
2003年12月19日 · β-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first …
Refined structures of β-ketoacyl-acyl carrier protein synthase III
2001年3月16日 · β-Ketoacyl-acyl carrier protein synthase III (FabH) is a condensing enzyme that plays central roles in fatty acid biosynthesis. Three-dimensional structures of E. coli FabH in …
β-酮脂酰-ACP合成酶（FabH）抑制剂研究进展 - 化学进展
其中β-酮脂酰-ACP合成酶Ⅲ(KAS Ⅲ，FabH)控制着细菌脂肪酸生物合成的起始步骤，普遍存在于病原体中且在人体中无其同源蛋白，成为新型抗菌药物靶标研究的热点。抑制FabH酶活性的 …
β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is a …
2000年1月15日 · Two genes that were predicted to encode homologs of the β-ketoacyl-acyl carrier protein synthase III of Escherichia coli (eFabH) were identified in the Bacillus subtilis …
Beta-ketoacyl-acyl carrier protein synthase III (FabH) is ... - PubMed
2003年12月19日 · beta-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first …
Structure-Based Design, Synthesis, and Study of Potent Inhibitors …
FabH, β-ketoacyl-ACP synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative …
作为潜在 β-酮酰基-酰基载体蛋白合酶 III (FabH) 抑制剂的新型酰胺 …
Fatty acid biosynthesis is essential for bacterial survival. Of these promising targets, β-ketoacyl-acyl carrier protein (ACP) synthase III (FabH) is the most attractive target. FabH would trigger …
Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from
1998年3月9日 · We report herein the purification and characterization of the thiolactomycin-sensitive S. glaucescens FabH. Our results showed that Streptomyces FabH is able to utilize …
发现新型细菌FabH抑制剂（吡唑-苯并咪唑酰胺衍生物）：设计， …
FabH酶催化脂肪酸生物合成的第一步，这对于细菌的生存至关重要。 因此，FabH已被确定为开发新型抗菌剂的有吸引力的靶标。 我们在这里提出了一种有前景的，具有低毒性和强效FabH抑 …
β-酮脂酰-acp合成酶（fabh）抑制剂的研究进展 - 豆丁网
2016年5月16日 · 其中β2酮脂酰2ACP合成酶Ⅲ (KASⅢ,FabH)控制着细菌脂肪酸生物合成的起. 始步骤,普遍存在于病原体中且在人体中无其同源蛋白,成为新型抗菌药物靶标研究的热点。 抑 …