Intracellular lipid chaperones dictate the destiny of lipids. Also known as fatty acid-binding proteins (FABPs), these are a group of proteins that coordinate lipid trafficking and...

2015年8月11日 · In this Review we discuss the roles and regulation of both intracellular and extracellular FABP actions, highlighting new insights that might direct drug discovery efforts and opportunities for...

Fatty Acid Binding Proteins (FABPs) are proteins that help transport and solubilize long-chain fatty acids and their CoA-esters within cells. They also act as receptors for these fatty acids and are involved in the regulation of certain cellular processes. You might find these chapters and articles relevant to this topic.

Purpose of review: Fatty acid-binding proteins (FABPs) are a family of small, abundant proteins with highly tissue-specific expression patterns whose different functions remain incompletely understood.

In this article, we focus on fatty acid-binding proteins (FABPs) derived from metabolically active cells, especially FABP4, and discuss both the significant role of FABP4 in pathophysiological insights and its usefulness as a biomarker in the context of …

Fatty-acid-binding proteins (FABPs) are a class of low-molecular-weight intracellular proteins that play a role as a transporter by binding to hydrophobic ligands, typically fatty acids, with different affinities, and are involved in the metabolism of these fatty acids (FAs).

2020年8月20日 · Fatty acid binding proteins (FABPs) serve as intracellular chaperones for fatty acids and other hydrophobic ligands inside cells. Recent studies have demonstrated new functions of individual members of the FABP family.

Fatty acid binding proteins (FABPs) are small, water soluble proteins that bind long chain fatty acids and other biologically active ligands to facilitate intracellular localization. Twelve FABP family members have been identified to date, with 10 isoforms expressed in humans.

Here, we discuss the central role of lipid chaperones — the fatty acid-binding proteins (FABPs) — in lipid-mediated biological processes and systemic metabolic homeostasis through the regulation of diverse lipid signals, and highlight their therapeutic significance.

2015年12月1日 · Liver fatty acid binding protein (FABP), also known as L-FABP or FABP1 is a 14 kDa soluble protein abundantly found in the cytoplasm of hepatocytes, and to a lesser extent in the nucleus (1, 2) and outer mitochondrial membrane (1, 3).