2017年8月1日 · Fowl adenovirus (FAdV) serotype-4, one of 12 FAdV subtypes, is the causative agent of hydropericardium syndrome (HPS), a severe disease in broiler chickens that is characterized by the accumulation of a clear, straw-colored fluid in the pericardial sac, as well as nephritis and hepatitis (Fig. 1).

2024年4月1日 · Fowl adenovirus serotype 4 (FAdV) is highly pathogenic and lethal to chickens, especially broilers, which has emerged as one of the most important economic losses for the poultry industry in the past few years. Although inactivated vaccines have been widely used to control FAdV diseases, with the passage of time and the advancement of ...

2018年12月5日 · Our results clearly demonstrated that the virulence of the novel highly pathogenic FAdV-4 strain was independent of the 1966-bp deletion and that the fiber2 and hexon genes have crucial roles in FAdV-4 pathogenicity.

Hepatitis-hydropericardium syndrome (HHS) caused by hypervirulent fowl adenovirus 4 (FAdV-4) have been causing great economic losses to Chinese poultry industry since 2015. Elucidation of the pathogenesis of FAdV-4 will lay solid foundation for developing attenuated FAdV-4 vaccine and vaccine vector …

The GX2020-019 strain of fowl adenovirus serotype 4 (FAdV-4) was isolated from the liver of chickens with hydropericardium hepatitis syndrome in Guangxi Province, China, and was purified by plaque assay three times. Pathogenicity studies showed that ...

2019年10月28日 · Fowl aviadenoviruses (FAdVs) are classified into five species (A-E) and 12 serotypes (FAdV-1 to 8a and -8b to 11) [1, 2]. FAdVs infects mostly 3–6-weeks-old broilers [3, 4], and is readily transmitted both horizontally by the fecal …

2018年2月24日 · Fowl adenovirus 4 (FAdV-4) is associated with economically important poultry diseases. Recent studies of fully sequenced genomes of FAdV-4 isolates suggest potential genomic regions associated with virulence and amenable for …

Hypervirulent fowl adenovirus serotype 4 (FAdV-4)-induced hepatitis-hydropericardium syndrome (HHS) with high mortality causes huge economic losses to the poultry industry worldwide. However, commercially available vaccines against FAdV-4 infection remain scarce. Here, we prepared a subunit vaccine …

Fowl adenovirus 4 (FAdV-4) is associated with economically important poultry diseases. Recent studies of fully sequenced genomes of FAdV-4 isolates suggest potential genomic regions associated with virulence and amenable for manipulation and vector development.

2022年11月1日 · Fowl adenoviruses (FAdVs) are non-enveloped and double-stranded linear DNA viruses belonging to the genus Aviadenovirus. Basing on restriction enzyme digest patterns and serum cross-neutralization tests, FAdVs have been clustered into five species (FAdV-A ∼ E) and 12 serotypes (FAdV-1–7, FAdV-8a, FAdV-8b, FAdV-9–11).