Vogt-Koyanagi-Harada (VKH) disease is defined as a bilateral granulomatous panuveitis, with or without extraocular manifestations, affecting young adults. Vogt in 1906 and Koyanagi in 1929 described the same disorder independently. It is characterized by chronic anterior uveitis, alopecia, vitiligo, and dysacusia.

2019年3月20日 · Fundus autofluorescence (FAF) showing (a) increased signal corresponding to areas of exudative retinal detachment in acute VKH. Chronic VKH can show both ( b ) hypoautofluorescence in the form of peripapillary atrophy and nummular scars and ( c ) hyperautofluorescence in subretinal fibrosis and RPE proliferation

Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele.

2025年1月11日 · To determine whether fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) imaging allows better assessment of RPE and outer retina (OR) in subjects with chronic VKH compared to examination and angiography alone.

2014年1月9日 · In acute VKH disease, fundus autofluorescence (FAF) shows hyperautofluorescence in the macula coupled with hypoautofluorescence in the areas of ERD Citation [110,111]. The abnormal FAF returns to normal at 6 months after corticosteroid treatment.

VKH恢复期FAF检查见自发荧光分布恢复至正常状态 (34.78%),或者高自发荧光的强度减低范围缩小 (39.13%) (平均面积减小了55.2%,相对荧光强度减低了46.52%)。 6只眼病变范围仅剩一些点状高自发荧光颗粒散在分布 (26.09%)。 SD-OCT视网膜下积液明显减少甚至消失 (相对入院时积液量平均减少69.5%)。 并且FAF荧光强度与SD-OCT中视网膜下积液呈正相关 (r=0.626,P<0.05)。 结论眼底荧光造影、眼底自发荧光成像联合SD-OCT可以提高VKH诊断准确率。 FAF、SD-OCT等 …

Peripheral FAF abnormalities are frequent in chronic VKH and are readily revealed by wide-field FAF imaging and manifesting with distinct patterns. Further investigation in prospective studies is warranted.

FAF photography non-invasively visualised sequential metabolic and functional changes in the retinal pigment epithelium (RPE) in acute VKH disease. The results suggest that early and sufficient treatment with a high-dose steroid might prevent persistent RPE damage. In addition, NIR-FAF can be an alt …

2021年1月20日 · To evaluate the value of fundus autofluorescence (FAF) imaging combined with spectral domain optical coherence tomography (SD-OCT) in diagnosis, prognostic assessment and follow-up observation of acute Vogt-KoyanagiHarada (VKH) disease.

2021年3月15日 · 摘要： 目的 深入探讨眼底自发荧光联合频域光学相干断层扫描在急性Vogt-Koyanagi-Harada综合征(VKH)预后评估和随诊观察中的作用.方法 收集我院2018年5月～2019年11月间12例(23只眼)急性VKH病例,包括详细的病史、最佳矫正视力、裂隙灯、眼底照相、SD-OCT、眼底荧光造影 ...