2017年4月15日 · Protein target information for Probable ubiquitin carboxyl-terminal hydrolase FAF-X (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the USP9X gene. [5][6] This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin -specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation.

该基因是肽酶 C19 家族的成员，编码一种类似于泛素特异性蛋白酶的蛋白质。虽然这个基因位于 X 染色体上，但它逃避了 X 失活。该基因的突变与特纳综合征有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

2024年12月25日 · USP9X (Ubiquitin Specific Peptidase 9 X-Linked) is a Protein Coding gene. Diseases associated with USP9X include Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted and Intellectual Developmental Disorder, X-Linked 99. Among its related pathways are Gene expression (Transcription) and Signaling by Rho GTPases.

2019年3月4日 · USP9X regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. The antibody is specific to USP9X. It has no cross reaction to USP9Y. Proteintech's Rabbit Recombinant USP9X antibody is validated in WB, IF/ICC, IP, ELISA and shows reactivity with human, mouse, rat samples.

2018年4月30日 · Here, we use affinity purification and mass spectrometry analysis to identify probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) as an interacting protein of the core clock protein aryl hydrocarbon receptor nuclear translocator-like protein 1 …

2023年11月30日 · Gene ID: 132659055, updated on 30-Nov-2023. Summary Other designations. probable ubiquitin carboxyl-terminal hydrolase FAF-X

Immunofluorescence analysis of Probable ubiquitin carboxyl-terminal hydrolase FAF-X was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.01% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature.

Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains.

USP9X is an important regulator of centrosome biogenesis and USP9X/CEP131 plays a critical role in breast carcinogenesis. High USP9X expression is associated with Pancreatic Ductal Adenocarcinoma.