Fah Knockout Animals as Models for Therapeutic Liver Repopulation
Immune deficient Fah-knockout mice can be repopulated with human hepatocytes, creating "mice with human livers". These chimeric animals have become an important preclinical model for …
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice ...
2007年7月29日 · To provide a broadly useful hepatic xenorepopulation system, we generated severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice. After …
018454 - FAH[Δexon9] NRG Strain Details - The Jackson Laboratory
018454 NOD.Cg- Rag1 tm1Mom Fah em1Mvw Il2rg tm1Wjl /MvwJ These FNRG mice contain a ZFN-mediated mutation that disrupts the Fah gene, and knock-out alleles of the Rag1 and …
Induction of functional hepatocyte-like cells from mouse
2011年5月11日 · Notably, transplanted iHep cells repopulate the livers of fumarylacetoacetate-hydrolase-deficient (Fah−/−) mice and rescue almost half of recipients from death by restoring …
Fah-KO(M-NSG) - 南模生物
常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。
Genome editing with Cas9 in adult mice corrects a disease ... - Nature
2014年3月30日 · To investigate the potential of CRISPR-Cas9–mediated in vivo genome editing in adult animals, we used a mouse model of hereditary tyrosinemia type I (HTI), a fatal genetic …
NPG-Fah - 可诱导肝损伤小鼠 - 维通达生物技术有限公司
NPG-Fah敲除小鼠，是维通达公司自主研发的一系列肝脏损伤免疫缺陷小鼠模型之一。 小鼠Fah基因位于7号染色体，采用CRISPR-Cas9技术在Fah基因1号外显子上编辑产生indel 引起移码突 …
Fah KO Mice - Metabolic Disease Models for Tyrosinemia …
Explore Cyagen's Fah KO mice for studying tyrosinemia type 1 and liver-related diseases. Ideal for gene therapy and liver stem cell research.
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice
To provide a broadly useful hepatic xenorepopulation system, we generated severely immunodeficient, fumarylacetoacetate hydrolase (Fah)-deficient mice. After pretreatment with …
Hedgehog signaling pathway regulates liver regeneration in the Fah ...
In the present study, we also found that Fah-/-mice withdrawal NTBC and transplanted with human hepatocytes (NTBC-OFF Fah-/-mice with HHT) gradually gained weight by six weeks …