In an effort to address this need, we have developed the fat attenuation index (FAI), a CT biomarker that detects vascular inflammation by analyzing the three-dimensional changes of CT attenuation from the perivascular adipose tissue (PVAT) …

2019年10月21日 · Patients with both HRP features (HRP+) and high FAI (FAI+) had a 6.3-fold (P<0.001) higher adjusted risk of MACE compared to individuals with neither of these risk features (HRP-/FAI-) (B). Furthermore, patients without HRP features but with high FAI (HRP-/FAI+) had a 4.9-fold (P<0.001) higher adjusted risk of MACE compared to the reference ...

2022年6月27日 · CCTA现在可用于斑块表征和易损、高危斑块（HRP）的检测，或通过应用计算流体动力学或负荷CT灌注（CTP）成像对冠状动脉病变进行功能评估，甚至可用于指导慢性完全闭塞的冠状动脉干预。 最近，通过冠状动脉周围脂肪成像检测冠状动脉炎症的新指标提供了前所未有的能力，可以通过标准CCTA图像的后处理来评估潜在的血管生物学过程。 这些CCTA成像的新应用不仅最大限度地提高了该模式的诊断率，而且也提高了其预后预测价值。 本文总结了心 …

2019年7月16日 · By detecting vascular inflammation, perivascular FAI enhances cardiovascular risk discrimination which could aid more cost-effective deployment of novel therapeutic agents. In this article, we present the existing non-invasive modalities for the detection of coronary inflammation and provide a practical guide for their use in clinical practice.

Coronary inflammation induces spatial changes in perivascular adipose tissue (PVAT) composition, which can be quantified with the perivascular Fat Attenuation Index (FAI). We hypothesized that perivascular FAI mapping can further …

The aggregate risk of high FAI and HRP features was greatly increased—by approximately 7.3-fold (96% CI 3.4-fold to 15.8-fold)—compared with the lowest risk group. These findings indicate that high FAI, in the context of patients with HRP features, identifies a small but …

右冠状动脉周围血管fai是典型的动脉炎症预测标志物（hr=2.15），高于血管周围fai临界点（-70.1亨氏单位）的患者心脏死亡率急剧上升（心血管死亡hr=9.04，全因死亡hr=2.55），该结果得到验证队列的确证。

2023年3月22日 · FAI values, MB parameters, and high-risk coronary plaque (HRP) characteristics were recorded. The subjects were classified into two groups (A and B) according to the absence or presence of coronary plaque in the segment proximal to the MB.

Mediation analysis suggested that higher SNA associates with MACE via a serial mechanism involving BMA, FAI, and HRP. Conclusions: SNA is significantly correlated with FAI and HRP in patients with CAD. Furthermore, such neural activity was associated with MACE, which was mediated in part by leukopoietic activity in the bone marrow, coronary ...

2021年2月25日 · In an effort to address this need, we have developed the fat attenuation index (FAI), a CT biomarker that detects vascular inflammation by analyzing the three-dimensional changes of CT attenuation from the perivascular adipose tissue (PVAT) around diseased coronary artery segments (14).