Filaggrin (fil ament aggr egating prote in) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. [3] .

丝聚蛋白（filaggrin, FLG）是人体皮肤角质层中连接角蛋白纤维的重要分子，在FLG单体协助连接下，角蛋白纤维规则地聚集，在表皮的最外层形成坚实的物理屏障，可以防止表皮水分的丢失和外界过敏物质的入侵。 [1] 基底细胞是未分化的幼稚细胞 (干细胞)，有活跃的分裂能力，新生的细胞向浅层移动过程中逐渐分化形成表皮其余几层的细胞，故基底层亦称生发层。 在电镜下观察，可见细胞质内有许多粗面内质网和张力细丝。 丝聚蛋白（Filaggrin）是角质层重要的成分,有角质 …

Filaggrin is synthesised as a giant precursor protein, profilaggrin (>400 kDa in humans), which is both heavily phosphorylated and insoluble. Profilaggrin is the main constituent of the electron-dense keratohyalin granules that are found within the granular layer of the epidermis (Fig. 1).

Filaggrin’s first function is to aggregate the tonofilaments, hence its name: filament aggregating protein. As the filaments are aggregated, they form into a lattice-like structure. When this reaches a critical size, it collapses on itself, rather like an ironing board being put away.

丝聚合蛋白最初以功能上无活性的丝聚合蛋白原（ profilaggrin，pFG）前体形式聚集在颗粒细胞的角质透明颗粒（keratohylin granules，KHG）中，在角质形成细胞由颗粒层向角质层分化过程中，在一些特异性磷酸酶及蛋白酶的作用下，经过去磷酸化以及蛋白水解处理过程，从丝聚合蛋白原转化为有活性的丝聚合蛋白。 丝聚合蛋白原是一组富含组氨酸的多聚蛋白，人的丝聚合蛋白原由10-12个重复的丝聚合蛋白单位组成，每个丝聚合蛋白单位由一个丝聚合蛋白序列加上19个氨基 …

2015年3月1日 · Filaggrin is a structural protein that is fundamental in the development and maintenance of the skin barrier. The function of filaggrin and its involvement in various cutaneous and extracutaneous disorders has been the subject of considerable research in recent years.

2024年2月1日 · Filaggrin is a 37-kD histidine-rich protein, expressed in the keratohyaline granules of the stratum granulosum, which, in the healthy SC forms aggregates with intermediate filaments of keratins 1 and 10, thereby contributing to the structural integrity of individual cells.17 Its precursor, profilaggrin, is encoded for by the FLG gene on chromoso...

In this review, we re-evaluate data focusing on the roles of filaggrin in the epidermis, as well as in AD. Filaggrin is important for alignment of keratin intermediate filaments, control of keratinocyte shape, and maintenance of epidermal texture via production of water-retaining molecules.

The interior of the corneocytes consists mainly of keratin filaments aggregated by filaggrin (FLG) protein. Next, together with several other proteins, FLG is cross-linked into a mechanically robust cornified cell envelope providing a scaffold for the extracellular lipid matrix.

2022年1月27日 · Research during the next three decades revealed the structure and function of a major protein in these granules, which was initially called the 'histidine-rich protein'. Steinert and Dale named the protein 'filaggrin' in 1981 because of …