2022年7月1日 · Fully automated synthesis of the theranostic pair [90 Y]Y/ [68 Ga]Ga-FAPI-46 was achieved on the Trasis EasyOne synthesizer with a radiochemical yield of 88 ± 7% and …

2021年4月16日 · A fully automated synthesis of [177Lu]Lu-FAPI derivatives was achieved on the Modular Lab Eazy (ML Eazy) with high radiochemical yield ([177Lu]Lu-FAPI-04; 88% ± 3, …

2024年4月1日 · Radio-thin layer chromatography (TLC) analyses were performed using 2 iTLC-SG strips (2 cm × 10 cm). A small drop of [68 Ga]Ga-FAPI-46 was placed on each strip 2 cm …

2022年7月29日 · The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical advantages. …

2022年7月29日 · The synthesis of [68 Ga]Ga-FAPI-46 was performed by mixing 50 µg of the FAPI-46 precursor with the [68 Ga]GaCl 3 solution directly eluted from the generator at 90 °C …

2023年8月11日 · [68Ga]Ga-FAPI-46 is a radiolabelled fibroblast activation protein inhibitor that selectively binds to fibroblast activation protein (FAP), which is overexpressed by cancer …

2022年7月29日 · Background The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical …

2024年4月1日 · Radiochemical purity (RCP) of [68Ga]Ga-FAPI-46 was analyzed by ascending chromatography using either ITLC-SG strip and 0.1 M ammonium acetate and methanol (1:1) …

2021年3月3日 · In this work, a fully-automated [¹⁷⁷Lu]Lu-FAPI synthesis has been well designed for the first time using commercially available synthesis module. In addition to the development …

近年来，基于喹啉设计的小分子fap抑制剂(fapinhibitor，fapi)显示出优秀的fap亲和力，多种68ga-fapi也在动物实验中显示了高度的肿瘤摄取和快速的体内清除，非常适用于体内成像，目前国 …