FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers. - Mechanism of Action & Protocol.

FAPI-46 是一种喹啉类成纤维细胞活化蛋白 (FAP) 靶向示踪剂。 使用放射性 68 Ga 或 177 Lu 标记的 FAPI-46 可用于多种癌症的肿瘤成像，具有更高的肿瘤摄取率和更长的肿瘤蓄积时间。

In this study, we evaluated the therapeutic effects of beta-emitter (177 Lu)-labelled FAPI-46 and alpha-emitter (225 Ac)-labelled FAPI-46 in pancreatic cancer models.

2023年1月3日 · Another recent report on [68 Ga]Ga-FAPI-46–positive and 18 F-FDG–negative findings in the lung after COVID-19 infection suggests the potential efficacy of FAPI PET in the evaluation of fibrous changes in the infectious or postinfectious lung (48).

Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study used 64Cu and 225Ac-labelled FAP inhibitors (FAPI-04) for a FAP-expressing ...

FAPI-46 能够选择性地与FAP结合，进而在生物体内追踪和标记含有FAP的细胞或组织。 成纤维细胞活化蛋白（FAP）是一种在多种癌症类型中过度表达的膜蛋白。

2023年6月1日 · In cohort 2 patients receive [68Ga]FAPI-46 PET/CT before and after neoadjuvant therapy, followed by surgical resection. The key objective for the study is to evaluate the performance [sensitivity, specificity, accuracy] of [68Ga]FAPI-46 PET imaging to detect tumor cells and FAP-expressing cells using histopathology and FAP immunohistochemistry ...

Fibroblast activation protein (FAP) is a crucial target for tumor diagnosis and treatment. FAP inhibitors (FAPIs) can selectively bind to FAP, and ligands with multiple targeting groups are anticipated to improve tumor-specific uptake. A dimeric …

2023年5月31日 · Potential improvement in the diagnostic accuracy in detecting the estrogen receptor status in metastatic and recurrent breast cancer using 18F-FES PET/CT in the US. Utility of artificial intelligence-based genomic classification of occult malignancies in clinical practice.

FAPI-46 是一种基于喹啉的靶向成纤维细胞活化蛋白 (FAP) 的放射性示踪剂。 FAPI-46 具有更高的肿瘤吸收率和增长的肿瘤积累时间。 FAPI-46 可用于多种不同癌症的肿瘤成像。 相关试剂产品 FAPI-15 FAPI-10 FAPI-09 FAPI-12 FAPI-11 FAPI-08 FAPI-07 FAPI-06 FAPI-05 FAPI FAPI-2 FAPI-4 FAPI-14 HYINC ...