fapi-46 是一种喹啉类成纤维细胞活化蛋白 (fap) 靶向示踪剂。使用放射性 68ga 或 177lu 标记的 fapi-46 可用于多种癌症的肿瘤成像，具有更高的肿瘤摄取率和更长的肿瘤蓄积时间。- 高纯度，全球文献引用。

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.

Jan 3, 2023 · Another recent report on [68 Ga]Ga-FAPI-46–positive and 18 F-FDG–negative findings in the lung after COVID-19 infection suggests the potential efficacy of FAPI PET in the evaluation of fibrous changes in the infectious or postinfectious lung .

In this study, we evaluated the therapeutic effects of beta-emitter (177 Lu)-labelled FAPI-46 and alpha-emitter (225 Ac)-labelled FAPI-46 in pancreatic cancer models. Methods: PET scans (1 h post injection) were acquired in PANC-1 xenograft mice (n = 9) after the administration of [18 F]FAPI-74 (12.4 ± 1.7 MBq) for the companion imaging.

一、试剂结构式 二、试剂简介 fapi-46是一种基于喹啉的靶向成纤维细胞活化蛋白（fap）的放射性示踪剂。它具有更高的肿瘤吸收率和增长的肿瘤积累时间，因此可用于多种不同癌症的肿瘤成像。 fapi-46能够选择性地与fa…

Feb 5, 2025 · fapi-46的设计思路是通过生物电子等排原理，将苯环链接的醚键替换为氮，三级胺在代谢上更有优势。 结果如预期， FAPI-46表现出了更好的肿瘤背景比值（tumor-to-background ratio，TBR），同时在体内的滞留时间也更长，这主要得益于氮原子的引入降低了正常器官的 ...

Fibroblast activation protein (FAP) is a crucial target for tumor diagnosis and treatment. FAP inhibitors (FAPIs) can selectively bind to FAP, and ligands with multiple targeting groups are anticipated to improve tumor-specific uptake. A dimeric …

This study revealed therapeutic effects of [177 Lu]FAPI-46 and [225 Ac]FAPI-46 in PANC-1 xenografts, while the impact of [177 Lu]FAPI-46 appeared slow but lasted longer. Beta therapy and alpha therapy targeting FAP can be a potential treatment for pancreatic cancers and needs further evaluation to find the best combination of fast FAP kinetics ...

3 days ago · Introduction Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) in the adrenocortical carcinoma (ACC) microenvironment may be used as potential therapeutic targets. This study investigated the diagnostic potential of four FAPi derivatives i.e. DOTA-FAPi-46 (FAPi46), DOTA.SA.FAPi (SA.FAPi), DATA5m.SA.FAPi (DATA.FAPi) and DATA5m.C4.FAPi (C4.FAPi) and compared ...

Mar 18, 2025 · FAPI imaging is gradually becoming an important imaging agent in the diagnosis of oncological diseases, and this review summarizes the existing literature on FAPI PET/CT imaging for the diagnosis of various malignant diseases. ... (2022) A 68 Ga-FAPI-46 PET/CT imaging pitfall in assessing residual gastric cancer early after chemotherapy. Clin ...