2022年7月1日 · Trisodium citrate 1 M solution (pH 5) was applied as eluent to determine free [68 Ga]Ga 3+ ions at Rf ≥0.8 and [68 Ga]Ga-FAPI-46 at Rf ≥ 0.2 (Fig. 6 d). Both TLC methods showed for [90 Y]Y-FAPI-46 as well as for [68 Ga]Ga-FAPI-46 a radiochemical purity >99%.

2021年4月16日 · A fully automated synthesis of [177Lu]Lu-FAPI derivatives was achieved on the Modular Lab Eazy (ML Eazy) with high radiochemical yield ([177Lu]Lu-FAPI-04; 88% ± 3, [177Lu]Lu-FAPI-46; 86% ± 3). Chromatographic analysis indicated the formation of radiosynthesis with an absolute radiochemical purity (99%).

2022年7月29日 · The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical advantages. [68 Ga]Ga-FAPI-46 is a new radiotracer for

2024年5月13日 · The present work describes the formulation of a lyophilized Fibroblast Activation Protein Inhibitor-4 (FAPI-4) kit for preparation of [68Ga]Ga-FAPI-4 in high radiochemical yield (RCY) using either generator or cyclotron produced 68GaCl3, suitable for Positron Emission Tomography (PET) based diagnosis of cancers over-expressing Fibroblast ...

基于 FAPα抑制剂（FAPI）的 PET/CT显像因受血糖影响小、肿瘤摄取迅速及较高的肿瘤/背景比值（TBRs）等特点，在临床中显示出良好的应用前景。 本综述旨在详细探讨FAPI成像技术的分子基础、发展历程、在各种癌症类型中的临床应用及面临的挑战。 1. FAPI成像的分子基础及发展历程. FAPα高表达于多种恶性肿瘤微环境中的CAFs表面，如乳腺癌、结肠癌和胰腺癌[4-6]，但在正常组织和良性肿瘤中，FAPα的表达通常很低或根本不存在。 靶向FAPα的分子影像正成为一种癌 …

2023年8月11日 · [68Ga]Ga-FAPI-46 is a radiolabelled fibroblast activation protein inhibitor that selectively binds to fibroblast activation protein (FAP), which is overexpressed by cancer-associated fibroblasts (CAFs) in the tumour microenvironment.

2020年12月17日 · [68 Ga]Ga-FAPI-46 is a promising radiopharmaceutical for in vivo detection of the fibroblast activation protein by positron emission tomography. Until now, the synthesis of [68 Ga]Ga-FAPI-46 has been only performed manually.

2022年8月1日 · In this study we performed automated synthesis of [68Ga]Ga-DATA.SA.FAPi, a FAPi linked to the hybrid chelator DATA5m via a squaric acid as well as the first use of 68Ga-DATA FAPi in patients.

近年来，基于喹啉设计的小分子fap抑制剂(fapinhibitor，fapi)显示出优秀的fap亲和力，多种68ga-fapi也在动物实验中显示了高度的肿瘤摄取和快速的体内清除，非常适用于体内成像，目前国内临床各家医院采用的是金属核素68ga标记fapi的化合物，由于68ga由发生器产生 ...

FAPI-46 是一种喹啉类成纤维细胞活化蛋白 (FAP) 靶向示踪剂。 使用放射性 68 Ga 或 177 Lu 标记的 FAPI-46 可用于多种癌症的肿瘤成像，具有更高的肿瘤摄取率和更长的肿瘤蓄积时间。 * Please select Quantity before adding items. • Appl Radiat Isot. 2024 Feb 1:206:111211. [Abstract] FAPI-46 is a quinoline-based fibroblast activation protein (FAP) -targeted tracer.