Abstract Background. 68 Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. It has shown significant tumor uptake and high sensitivity in lesion detection across a range of cancer types. We aimed to compare the diagnostic value of 68 Ga-FAPI and 18 F-FDG PET/CT in common gynecological malignancies.

This was a retrospective study of 43 patients with various malignancies who underwent 68 Ga-FAPI-46 PET/CT. The tumor types are summarized in Table 1. All imaging was performed at a single center, and all patients were referred by their attending oncologist or radiation oncologist for 1 of 3 reasons: to improve delineation of the target volume ...

2024年11月13日 · In this review we provide an overview of the current status of FAPI-PET, beginning with a brief description of FAP and FAP tracers, the importance of tumor stroma, and the potential clinical...

2019年4月6日 · FAP is overexpressed by cancer-associated fibroblasts of several tumor entities. Here, we quantify the tumor uptake on 68 Ga-FAPI PET/CT of various primary and metastatic tumors to identify the most promising indications for future application.

2025年3月16日 · 近日，北京大学化学与分子工程学院应用化学系刘志博团队及合作者在肿瘤学领域权威期刊Cancer Discovery（IF = 29.7）发表题为“CTR-FAPI PET enables precision management of medullary thyroid carcinoma”的研究论文。这项临床研究表明，靶向共价放射性药物CTR-FAPI能显著提高甲状腺髓样癌（MTC）转移病灶的检出率和识别 ...

2025年3月14日 · Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is a relative scarcity of clinical studies on 99mTc-labeled FAP SPECT tracers. The existing quinoline-derived 99mTc-FAPI tracer exhibits relatively low tumor uptake and suboptimal pharmacokinetic properties, which restrict ...

2025年3月21日 · Patients. This is a secondary report of a single-center, retrospective trial evaluating the relationship between PD-L1 expression and [18 F]AlF-NOTA-FAPI-04 (denoted as [18 F]FAPI) PET/CT or [18 F]FDG PET/CT.Patients diagnosed with lung cancer at the affiliated Cancer Hospital of Shandong First Medical University between …

5 天之前 · The FAPI PET uptake and FAP immunostaining intensity have been suggested to be related to malignancy in pancreatic tumors . Considering that pulmonary metastasis represents evidence of oncological aggressiveness, it seems logical that the FAP intensity of pulmonary metastatic nodules tended to be higher than that of other intrathoracic SFTs.

2024年9月11日 · Fibroblast activation protein-α (FAPα) is an enzyme usually not expressed by normal tissues, but overexpressed stromal fibroblasts typically present in many epithelial cancers, and may potentially represent an attractive target for diagnostic and therapeutic uses.

2025年1月11日 · Results: Our findings indicated that FAP-targeting radiopharmaceuticals can induce DNA double-strand breaks and upregulate PD-L1 expression, with 177 Lu-DOTA-2P (FAPI) 2 proving to be more effective than 68 Ga-DOTA-2P (FAPI) 2.