Dec 25, 2024 · FASLG (Fas Ligand) is a Protein Coding gene. Diseases associated with FASLG include Autoimmune Lymphoproliferative Syndrome and Immunodeficiency 98 With Autoinflammation, X-Linked. Among its related pathways are MIF Mediated Glucocorticoid Regulation and Regulation by c-FLIP.

Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils, breast epithelial cells, vascular endothelial cells and natural killer (NK) cells.

Jan 4, 2025 · The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death.

Fas配体，又名TNFSF6、FasL或CD95L，是肿瘤坏死因子 (TNF)家族中的一员。 它是一个在细胞毒性T淋巴细胞上表达的同源三聚体II型跨膜蛋白。 外基质金属蛋白酶MMP-7在保守裂解位点裂解膜结合的FasL可生成可溶性Fas配体。 Fas配体/受体的相互作用在调节免疫系统和癌症的进展中发挥重要作用。 它通过FasR的三聚体化产生信号，这个三聚体化通常会导致细胞凋亡或死亡。 由Fas-Fas配体结合所引起的凋亡在免疫系统的调节中发挥至关重要的作用，它的功能包括T细胞 …

Sep 19, 2024 · The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers.

Dysfunction of the FAS-FASLG pathway causes a lymphoproliferative disorder with autoimmunity called Autoimmune lymphoproliferative syndrome (ALPS) mainly caused by FAS mutations. The goal of this review is to describe the genetic bases of the ...

Feb 8, 2025 · The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death.

Mar 21, 2023 · FasL 是能够结合到死亡受体 TNFRSF6/FAS 的细胞因子，在 T-cell 发育中介导其由于细胞毒性引起的凋亡。 FasL基因位于1号染色体，与 OX-40L 基因相邻，由5个外显子组成。 FasL只表达于活化T淋巴细胞，其它细胞如B细胞、巨噬细胞、成纤维细胞、内皮细胞以及胸腺细胞都不表达FasL，但在小鼠的睾丸组织中，却可见到高表达的FasL。 佛波酯 (PMA)和 离子霉素 可以促进FasL表达， 环孢素A 可以抑制FasL的表达。 FasL是能够结合到死亡受 …

The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).

fas/faslg信号通路对免疫系统的调节至关重要，包括t细胞的激活诱导细胞死亡（aicd）和细胞毒性t淋巴细胞诱导的细胞死亡。 它还与几种癌症的发展有关。