Nov 15, 2018 · High-fat high-fructose diet feeding and PLP administration changed the composition of caecum microbiota (A). PLP treatment rescued the decreased plasma VB12 level in high-fat high-fructose diet fed mice (B), and stimulated the proliferation of the species of Porphyromonas with VB12 synthetic capability (C). Each bar represent the mean ± SD, n ...

Feb 25, 2025 · Our study found that PLP levels were inversely associated with LDL-C levels and positively associated with HDL-C levels; specifically, an increase in PLP levels corresponded with higher HDL-C levels. Additionally, a nonlinear relationship between PLP and HDL-C …

VitB6 works as a cofactor for more than 150 enzyme reactions involved in amino acid, glucose, and fat metabolism. PLP is the biologically active form of VitB6 and low levels of plasma PLP are associated with cardiovascular disease, stroke, venous thrombosis, rheumatoid arthritis, inflammatory bowel disease, diabetes, and several cancers.

磷酸吡哆醛 （pyridoxal phosphate，PLP）是 维生素B 6 的活性形式。 这种维生素主要包括三种天然 有机化合物： 吡哆醛 、 吡哆胺 与 吡哆醇 [1]。 磷酸吡哆醛参与催化的几种反应有： 转氨基作用 、α- 脱羧作用 、β- 脱羧作用 、β- 消除作用 、γ- 消除作用 、 消旋作用 以及 羟醛反应。 磷酸吡哆醛在所有 转氨基作用 反应以及一些 氨基酸 的 脱羧 与 脱氨 反应中充当辅酶的角色。 磷酸吡哆醛的醛基与氨基转移酶中特定赖氨酸基团的ε-氨基之间形成 希夫碱 键（内部醛亚胺）。 氨基 …

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. [5]

Mar 1, 2024 · Polysaccharides from Phellinus linteus (PLP) have been found to have anti-diabetes effects, but the mechanism has not been elucidated. The purpose of this study was to investigate the mechanism of PLP on T2DM through the gut microbiota and bile acids metabolism.

The aspartate aminotransferase in E. coli requires PLP for proper stabilization in a native structure, and as the protein disassociates into a partially folded intermediate, PLP is reduced into a pyridoxyllysine (PPL) derivative to ‘lock’ the co-factor in place to further stabilize the protein .

Jun 17, 2022 · Given that pyridoxal 5’-phosphate (PLP), a biologically active form of vitamin B6 (hereinafter defined as Vit-B6), is a well-known cofactor of the key enzymes (including Kyn aminotransferases ...

Dec 12, 2023 · 磷酸吡哆醛（plp）是维生素b6的一种衍生物，是维生素b6参与蛋白质、脂肪和碳水化合物的多种代谢反应的一种活性形式。 其是氨基酸代谢中的转氨酶及脱羧酶的辅酶。

Polysaccharides from Phellinus linteus (PLP) have been found to have anti-diabetes effects, but the mechanism has not been elucidated. The purpose of this study was to investigate the mechanism of PLP on T2DM through the gut microbiota and bile acids metabolism.