Dec 1, 2022 · Fatty acid transport proteins are involved in the progression of cancers through some proposed mechanisms that increase the proliferation, metastasis, and invasion of cancer cells, which affect target organs such as the breast, prostate, bladder, liver, kidney, and lung.

Apr 17, 2019 · Here we report that mouse and human PMN-MDSCs exclusively upregulate fatty acid transport protein 2 (FATP2). Overexpression of FATP2 in PMN-MDSCs was controlled by granulocyte–macrophage...

FATPs (fatty acid transport proteins) are a group of proteins involved in fatty acid uptake, mainly localized within cells and the cellular membrane, and have a key role in long-chain fatty acid transport. FATPs are composed of six isoforms that are tissue-specific and encoded by a …

Jun 28, 2012 · 目前已发现协助长链脂肪酸转运的载体膜蛋白主要包括脂肪酸转运蛋白家族 帆 能 等 等 、脂肪酸转位酶 哆 等 和膜脂肪酸结合蛋白 等 。

一组提议用于转运脂肪酸的蛋白质是六成员脂肪酸转运蛋白 (fatp) 家族。 这些蛋白质之所以如此命名是因为当过度表达时，宿主细胞表现出更高的放射性或荧光脂肪酸的增加率。

Aug 1, 2001 · Fatty acid transport proteins are a family of transmembrane proteins that enhance LCFA uptake and are produced in all fatty acid-utilizing tissues. Here, we review our current understanding of the function, expression patterns and regulation and subcellular localization of this interesting family of proteins.

Jul 11, 2003 · Fatty acid transport proteins (FATPs/solute carrier family 27) are integral transmembrane proteins that enhance the uptake of long-chain and very long chain fatty acids into cells. In humans FATPs comprise a family of six highly homologous proteins, hsFATP1–6, which are found in all fatty acid-utilizing tissues of the body.

The fatty acid transport proteins (FATP) are classified as members of the Solute Carrier 27 (Slc27) family of proteins based on their ability to function in the transport of exogenous fatty acids. These proteins, when localized to the plasma ...

迄今为止，FATP1，FATP2和FATP4已被用作选择小分子抑制剂的靶标，目的是治疗胰岛素抵抗和减轻饮食中脂肪酸的吸收。 针对FATP1和FATP4的一些研究基于这些蛋白质的内在酰基CoA合成酶活性，而不是直接运输。 虽然几类化合物被确定为潜在的脂肪酸转运抑制剂，但使用小鼠模型进行的体内研究未能提供证据证明这些化合物可有效阻断或减弱脂肪酸转运。 针对FATP2的研究使用了天然存在的剪接变体FATP2b，由于外显子3的缺失，它缺乏内在的酰基CoA合成酶，但在脂肪 …

Adipocyte-derived lipids are taken up by FATP proteins that are aberrantly expressed in melanoma. Inhibition of FATPs decreases melanoma lipid uptake, invasion, and growth. We provide a mechanism for how stromal adipocytes drive tumor progression and demonstrate a novel microenvironmental therapeutic target.