FATP是脂肪酸转运蛋白（fatty acid transport proteins），主要用于运输长链脂肪酸，至少有六种（FATP1-6），各有不同的专一性和组织分布。 脂肪酸与转运蛋白结合后，表观pKa从水溶液中的4.5升高到7.6，结果大约一半的脂肪酸不带电荷，从而能够穿过磷脂双层。 在质膜的内表面，脂肪酸可以与胞质脂肪酸结合蛋白（FABPc）或小窝蛋白1（Caveolin-1）结合。 FABPc使脂肪酸保持可溶性，并可以在细胞内运输到各个细胞区室（细胞器）。 脂肪酸氧化前要先活化，即生成 …

2020年9月21日 · Restricting CD36 at either palmitoylated or depalmitoylated state eliminates its FA uptake activity, indicating an essential role of dynamic palmitoylation of CD36. Furthermore, blocking...

2012年6月28日 · 目前已发现协助长链脂肪酸转运的载体膜蛋白主要包括脂肪酸转运蛋白家族 帆 能 等 等 、脂肪酸转位酶 哆 等 和膜脂肪酸结合蛋白 等 。

Fatty acid translocase/CD36 (FAT/CD36) may interact with CPT1 and contribute to fatty acid import into mitochondria in muscle. Here, we demonstrate that another membrane-bound fatty acid binding protein, fatty acid transport protein 1 (FATP1), collaborates with CPT1 for fatty acid import into mitochondria.

In vivo FABPpm, FAT/CD36, and FATP1 and -4 each increased the rate of fatty acid transport in rat skeletal muscle, with FAT/CD36 and FATP4 being the most effective. Each of the transporters also contributed to increasing fatty acid oxidation, but not esterification, with the greatest effects being attributed to FAT/CD36 and FABPpm.

2024年11月20日 · Fatty acid transporters such as CD36, FABP4, and FATP1 are under transcriptional regulation by PPARγ . Indeed, Cd36, Fabp4, and Fatp1 gene expression was shown to increase in 3T3-L1 adipocytes treated with PPARγ agonists [33, 88]. Since N-3 PUFA can activate PPARγ in WAT, this provides a plausible mechanism by …

We compared the intracellular distribution and regulatory role of fatty acid transporter protein (FATP1) and fatty acid translocase (FAT/CD36) on muscle cell fatty acid metabolism. With the use of adenoviruses, FATP1 and FAT genes were delivered to …

Fatty acid translocase/CD36 (FAT/CD36) may interact with CPT1 and contribute to fatty acid import into mitochondria in muscle. Here, we demonstrate that another membrane-bound fatty acid binding protein, fatty acid transport protein 1 (FATP1), collaborates with CPT1 for fatty acid import into mitochondria.

2016年10月1日 · Myocardial uptake of long-chain fatty acids largely occurs by facilitated diffusion, involving primarily the membrane-associated protein CD36. Other putative fatty acid transporters, such as FABPpm, FATP1 and FATP4, also play a role, but their quantitative contribution is much smaller or their involvement is rather permissive.

To investigate the subcellular distribution of FAT/CD36, FATP1, FATP4, and caveolin-1 in 3T3-L1 adipocytes, we fractionated cell homogenates by a discontinuous iodixanol OptiPrep step gradient. We used antibodies against Na-K-ATPase, gp26/27, and calreticulin as markers for the plasma membrane, Golgi-network, and endoplasmic reticulum (ER ...