Steatosis is the histological feature that ties together all of the various forms of NAFLD (Figure 2A.), but is a common and completely non-specific lesion that may be seen in the background of many liver diseases.

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excessive fat accumulates in the liver of a patient without a history of alcohol abuse. NAFLD is etiologically associated with systemic and hepatic insulin resistance, and is regarded as a hepatic manifestation of metabolic syndrome[ 1 , 2 ].

In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed. Keywords: Fatty liver, Steatosis, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis, Fibrosis.

Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. [1] . Often there are no or few symptoms. [1][2] Occasionally there may be tiredness or pain in the upper right side of the abdomen. [1] .

2014年11月14日 · Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is the most common chronic liver disease, and the prevalence is rapidly increasing worldwide. Nonalcoholic steatohepatitis (NASH), the severe form of NAFLD, can progress to liver cirrhosis and hepatocellular car …

Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings.

The most common cause of fatty change in developed nations is termed metabolic dysfunction–associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver (NAFL) disease (diabetes mellitus, obesity, metabolic syndrome).

2023年1月1日 · Fat accumulates in the liver for several reasons. It most commonly involves increased delivery of free fatty acids to the liver, increased synthesis of fatty acids in the liver, decreased oxidation of FFA, or decreased synthesis or secretion of very-low-density lipoprotein.

Fatty liver disease includes non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), each of which is increasing in prevalence. Each represents a histological spectrum that extends from isolated steatosis to steatohepatitis and cirrhosis.

2007年2月1日 · Fatty liver disease is currently recognized as a common cause of liver test elevation, paralleling the worldwide ‘epidemic’ of obesity in adults and children.