2011年11月11日 · We show that Fbw7 directly binds Nrf1 through a Cdc4 phosphodegron and that enforced expression of Fbw7 promotes the ubiquitination and degradation of Nrf1. Conversely, depletion of endogenous Fbw7 leads to decreased Nrf1 ubiquitination and accumulation of Nrf1 protein.

FBW7 (F-box and WD repeat domain-containing 7) is an F-box protein that binds to key regulators of cell division and growth, including cyclin E, MYC, JUN and Notch. Most FBW7 substrates are...

FBW7通过靶向降解多种原癌蛋白如Brg1、Cyclin E、 C-myc、Notch、c-Jun、Mcl-1和SREBP等调控细胞增殖、凋亡及能量代谢等多种生物学过程中的关键分子而 发挥肿瘤抑制作用。本文将从FBW7靶向降解底物抑制肿瘤生长和FBW7突变、FBW7靶向降解底物突变和的

FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, ...

FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins—such as Notch, c-Myc, cyclin E and c-Jun—for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell ...

2014年10月10日 · Tumor suppressors with widespread impact on carcinogenesis control broad spectra of oncogenic pathways. Protein degradation is an emerging mechanism by which tumor suppressors regulate a diversity of pathways and is exemplified by the SCF Fbw7 ubiquitin ligase.

2012年3月21日 · FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primari...

2016年2月1日 · CSN subunits CSN5 and CSN6 regulate Cul1 deneddylation within SCF(Fbw7), and binding of glomulin to Rbx1 blocks its interaction with E2 ubiquitin-conjugating enzymes. Substrate-specific mechanisms modulate Fbw7-dependent turnover of Jun (via Rack1) and of N-Myc (via Aurora A kinase).

2018年4月6日 · In this study, we examined the expression pattern of FBW7 and its prognostic valve in glioma specimens, tested the inhibitory effect of FBW7 overexpression on cell malignancies of glioblastoma with special regard to TMZ chemoresistance, and, finally, explored the underlying mechanisms of FBW7 regulation in cell cycle, apoptosis and the related ...

2022年1月28日 · Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc degradation in cancers. Here, we identify a second Fbw7 phosphodegron at Myc T244 that is required for Myc ubiquitylation and acts in concert with T58 to engage Fbw7.