F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

2024年12月25日 · FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include Developmental Delay, Hypotonia, And Impaired Language and Colorectal Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Class I MHC …

2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA.

fbxw7是一种抑制肿瘤生长的scf e3泛素连接酶。 在大多数情况下，FBXW7识别磷酸化底物并促进它的泛素化降解。 FBXW7基因所编码的蛋白属于F-box蛋白家族的一员，为SCF（SKP1-cullin-F-box）型泛素连接酶的靶蛋白识别成…

4 天之前 · FBXW7是一种抑制肿瘤生长的SCF E3泛素连接酶。在大多数情况下，FBXW7识别磷酸化底物并促进它的泛素化降解【1】。目前报道，FBXW7主要通过泛素化降解几个关键促癌蛋白，包括c-Myc、MCL-1、c-Jun、Notch1和cyclin E而发挥抑癌功能。

FBXW7 can function as monomer or as a dimer and some studies have suggested that this may affect target selection and binding strength. In addition, dimerization of FBXW7 may play important roles in cancer cells whereby one copy is mutated. In fact, several studies have shown dominant negative functions for mutated FBXW7 alleles.

2025年2月9日 · FBXW7 is a significant tumor suppressor gene in renal cancer.FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis. Results establish that FBXW7 down-regulation is synthetic lethal with MYC, and that MYC is a critical target of FBXW7 in breast epithelial cells.

fbxw7 （F-box and WD repeat domain containing 7） 作为泛素蛋白酶体降解途径的重要识别因子之一，FBXW7的底物很多都是癌基因，例如cyclinE、 c－myc、c－jun及Notch等都是通过FBXW7介导的泛素蛋白酶体途径进行降解的，FBXW7突变和缺失能引起这些与癌细胞增殖相关基 …

该研究首次揭示了RPAP2的促癌特性，并阐明了泛素连接酶FBXW7通过靶向降解RPAP2来抑制肝癌细胞生长及调控肝脏细胞分化的分子机制，为靶向原癌蛋白RPAP2的治疗提供了新的策略。 在本研究中，研究者首先通过分析TCGA数据库中32种人类肿瘤样本，发现RPAP2的mRNA仅在肝癌患者中显著升高，且与患者的不良预后密切相关。...

2023年9月2日 · FBXW7 indirectly regulates breast cancer angiogenesis through its interaction with HIF-1α, and high HIF-1α expression is frequently observed in FBXW7-deficient breast cancers along with angiogenesis and migration, suggesting that normal FBXW7-HIF-1α binding is essential for remodeling normal vascular structure and tumor microenvironment (TME) .