Neonatal fragment crystallizable receptor - Wikipedia
The neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. [1] [2] [3] It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin.
FcRn: The architect behind the immune and non-immune …
The neonatal Fc receptor (FcRn) belongs to the extensive and functionally divergent family of MHC molecules. Contrary to classical MHC family members, FcRn possesses little diversity and is unable to present antigens. Instead, through its capacity ...
FcRn and its role as a therapeutic target - News-Medical.net
2021年11月10日 · In 1972, a receptor that transfers maternal IgG to newborns in the gut of neonatal rats was identified. It was later named as Neonatal Fc receptor (FcRn). FcRn expression at the time of...
In Translation: FcRn across the Therapeutic Spectrum - PMC
As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly reexamine the hitherto elucidated biological and thermodynamic ...
FcRn: The Architect Behind the Immune and Nonimmune …
2015年5月15日 · The neonatal FcR (FcRn) belongs to the extensive and functionally divergent family of MHC molecules. Contrary to classical MHC family members, FcRn possesses little diversity and is unable to present Ags. Instead, through its capacity to bind IgG and albumin with high affinity at low pH, it regulates the serum half-lives of both of these proteins.
CIN Corporate Identity Number FCRN, LLPIN, FLLPIN, GLN
GLN is the short form of "Global Location Number". FCRN is the short form of "Foreign Company Registration Number". LLPIN is the short form of "Limited Liability Partnership Identification Number".
The neonatal Fc receptor, FcRn, as a target for drug delivery and ...
FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important player in autoimmune disease, mucosal immunity, and tumor immune surveillance.
FcRn: the neonatal Fc receptor comes of age - Nature
2007年8月17日 · The neonatal Fc receptor for IgG (FcRn) is responsible for the transfer of passive humoral immunity from the mother to the newborn in rodents and humans. Throughout life, FcRn...
The Neonatal Fc Receptor (FcRn): A Misnomer? - Frontiers
FcRn functions as a recycling or transcytosis receptor that is responsible for maintaining IgG and albumin in the circulation, and bidirectionally transporting these two ligands across polarized cellular barriers.
The Role of FcRn in Antigen Presentation - PMC - National Center …
2014年8月27日 · In addition to the classical Fcγ receptors that bind IgG at the cell surface, the neonatal Fc receptor (FcRn) is a lifelong resident of the endolysosomal system of most hematopoietic cells where it determines the intracellular fate of both IgG and IgG-containing immune complexes (IgG IC).