Humanized FcRn Mouse Models for Evaluating Pharmacokinetics …
The humanized FcRn mouse models presented here provide a reliable tool for studying serum half-life of human/ized mAbs and other Fc-containing proteins.
The therapeutic age of the neonatal Fc receptor - Nature
2023年2月1日 · FcRn-deficient mice were protected from blistering in type VII collagen-immunization or passive antibody transfer EBA models, and these mice had lower levels of …
Utility of a human FcRn transgenic mouse model in drug ... - PubMed
Transgenic mice expressing human neonatal Fc receptor (hFcRn) have potential as a preclinical pharmacokinetic (PK) model to project human PK of monoclonal antibodies (mAbs).
FcRn Expression in Wildtype Mice, Transgenic Mice, and in …
Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss …
An Fc variant with two mutations confers prolonged serum half …
2022年11月1日 · In this study, we report a novel Fc variant that can confer improved dissociation capability at pH 7.4 while showing human FcRn binding affinity comparable to that of the …
Distribution of FcRn Across Species and Tissues - PubMed
The human FcRn transgenic mouse Tg276 showed a different and much more widespread staining pattern of FcRn. In addition, immunodeficiency and lack of IgG in SCID mice had no …
Pharmacokinetic prediction of an antibody in mice based on an in …
2020年10月1日 · Human FcRn transgenic mice and cynomolgus monkeys are frequently used to reveal the PK of candidate antibodies in vivo, and it is widely accepted that empirical …
Distribution of FcRn Across Species and Tissues - PMC
In this study, the distribution of FcRn was mapped across a set of species and selected genetically modified mouse lines.
Cross-species binding analyses of mouse and human neonatal Fc …
2010年2月12日 · The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular …
Blocking FcRn in humans reduces circulating IgG levels and
We generated, characterized, and assessed the effects of SYNT001, a FcRn-blocking monoclonal antibody, in mice, nonhuman primates (NHPs), and humans. SYNT001 decreased all IgG …