High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. [5][6][7] The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. [8] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

2024年12月25日 · FCGR1A (Fc Gamma Receptor Ia) is a Protein Coding gene. Diseases associated with FCGR1A include Peritonitis and Pharyngitis. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Regulation of actin dynamics for phagocytic cup formation.

2014年1月21日 · In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by FcγR recognition of immunoglobulins and immune complexes in the steady...

2025年2月8日 · Alveolar macrophages and Fc receptors (Fcgr1 and Fcgr3)-dependent elimination of influenza A virus-infected cells are essential for protection by influenza A virus anti-matrix protein 2 (M2) ectodomain IgG antibody.

2019年9月3日 · Here, we analyze >3000 lung tissue mononuclear cells expressing the high affinity immunoglobulin gamma Fc receptor (Fcgr1, CD64) by droplet-based single-cell RNA-sequencing (scRNA-seq) in adult...

CD64; FCG1; FCRI; CD64A; FCGR1; IGFR1; FcgammaRI. This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

2011年3月1日 · IgG FcRs are important mediators of immunity and play a key role during Ab-based immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG binding with high affinity. FcγRI exists as a complex of a …

Fcgr1 (45.2 cM) has been identified as a possible candidate gene for Idd10. Sequence analysis revealed 17 amino acid differences between NOD and C57BL/10 in addition to deletion of 75% …

2009年5月7日 · Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the...

2020年12月3日 · FCGR1A may be a potential prognostic biomarker and related to immune infiltration levels in diverse cancers, especially in CESC, CHOL, KIRC, and SKCM. Besides, FCGR1A may be involved in the activation, regulation, or induction of immune cells and diverse physiological and pathological processes.