Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of …

FcγRIIB is the only inhibitory FcγR. It is a low affinity receptor that binds immune-complexed IgG and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic …

2024年12月25日 · FCGR2B (Fc Gamma Receptor IIb) is a Protein Coding gene. Diseases associated with FCGR2B include Systemic Lupus Erythematosus and Malaria. Among its …

2020年1月14日 · Effector CD8 + T cells are important mediators of adaptive immunity, and receptor-ligand interactions that regulate their survival may have therapeutic potential. Here, …

利用抗体和抑制性Fc受体FcγRIIB之间的相互作用来优化共刺激激动活性代表了当前的最新前沿。 肿瘤坏死因子超家族 （TNFSF）及其受体超家族分别由19个配体和29个受体组成，在炎症、 …

2022年7月19日 · We demonstrate that signaling through the hFcγRIIB ITIM is dispensable for impairing monoclonal antibody (mAb)-mediated depletion of normal and malignant murine …

We demonstrate that signaling through the hFcgRIIB ITIM is dispensable for impairing monoclonal antibody (mAb)-mediated depletion of normal and malignant murine target cells through three …

FcgRIIB is a low-affinity Fcg receptor well known to be expressed on B cells, macrophages, dendritic cells (DCs), and granulocytes and is the sole inhibitory Fcg receptor (Nimmerjahn …

2013年11月14日 · 摘 要：FcγRIIB作为低亲和力IgG受体介导对多种免疫细胞功能的负反馈调节。 它的两种主要分子异. 构体IIB1、IIB2分布于不同的细胞表面并发挥不同的抑制效应。 FcγRIIB …

2023年8月23日 · We recently showed that FcγRIIB, the only inhibitory IgG-Fc receptor, is expressed on a population of highly differentiated effector CD8 + T cells in the tumors of mice …