2024年12月25日 · FCRL5 (Fc Receptor Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include Hairy Cell Leukemia and Lymphoma. Among its related pathways is Extrafollicular and follicular B cell activation by SARS-CoV-2. …

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. [5] [6] [7] FCRL5 has also been designated as CD307 (cluster of differentiation 307).

2024年1月12日 · Fc receptor-like 5 (FCRL5) is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions, offering an...

2025年2月8日 · FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. FcRL5 binds all …

2019年4月30日 · FCRL5 + atypical memory B cells (atMBCs) expand in many chronic human infections, including recurrent malaria, but studies have drawn opposing conclusions about their function. Here, in mice infected with Plasmodium chabaudi, we demonstrate expansion of an antigen-specific FCRL5 + population that is distinct from previously described FCRL5 ...

2025年1月4日 · FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs.

FCRL5+ atypical memory B cells (MBCs) expand in many chronic human diseases. Using tetramers to track rare antigen-specific cells, Kim et al. show that FCRL5+ MBCs are mature, optimally responsive cells that arise not only in response to infection and protein immunization in mice but also to immunization in humans.

FCRL5 plays a role in innate immunity by its ability to be induced by anti-Ig co-stimulation. Additionally, mAb-directed co-ligation of FCRL5 and the BCR shared with anti-CD40 and IL-2 stimulation enhanced the proliferation of B-cells during TLR9 stimulation .

2013年6月1日 · Fc receptor–like (FCRL) 5 regulates B cell Ag receptor signaling and has been reported to bind aggregated IgG. Using surface plasmon resonance, we analyzed the interaction of native IgG samples with FCRL5, revealing a complex binding …

Human FCRL5 binds intact IgG and modifies the strength of antigen receptor (BCR) signaling. Altering FCRL5 expression could therefore regulate the B cell response to antigen. In this study, we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism.