2024年12月25日 · FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein Coding gene. Diseases associated with FDFT1 include Squalene Synthase Deficiency and Smith-Lemli-Opitz Syndrome. Among its related pathways are superpathway of cholesterol biosynthesis and Metabolism of steroids.

该基因编码位于甲羟戊酸途径分支点的膜相关酶。 编码的蛋白质是胆固醇生物合成中的第一个特异性酶，在两步反应中催化两分子法尼基二磷酸二聚化形成角鲨烯。 [RefSeq 提供，2008 年 7 月] This gene encodes a membrane-associated Enzyme located at a …

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. [5] This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway.

2024年4月11日 · FDFT1 is a key downstream target of the fasting response and may be involved in CRC cell glucose metabolism. Title: Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.

FDFT1 is a key downstream target of the fasting response and may be involved in CRC cell glucose metabolism. We have demonstrated the differential relative expression levels of FDFT1 mRNA and protein in various types of cancer based on TMAs and IHC for protein expression, and qPCR analysis for the illustration of mRNA expression.

2020年4月20日 · We find that fasting upregulates the expression of a cholesterogenic gene, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), during the inhibition of CRC cell aerobic glycolysis and...

2025年2月3日 · Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) synthesizes squalene and participates in cholesterol biosynthesis. This study demonstrates the essential role of FDFT1 in cholesterol metabolism and...

这个基因编码一个位于甲羟戊酸途径分支点的膜关联酶。 编码的蛋白质是胆固醇生物合成中的第一个特异性酶，催化两个分子法尼酯二磷酸在两步反应中二聚形成角鲨烯。 [由RefSeq，2008年7月提供] Dir./Indir. DNA sequence and analysis of human chromosome 8. Complete sequencing and characterization of 21,243 full-length human cDNAs.

2024年7月30日 · FDFT1 is the initial enzyme in the cholesterol biosynthesis pathway. It plays a crucial role in synthesizing squalene, which is a key precursor in cholesterol production. This synthesis occurs through a two-step process. Initially, two molecules of farnesyl pyrophosphate (FPP) combine to form pre-squalene diphosphate (PSDP).

2024年7月30日 · FDFT1, also known as farnesyl diphosphate farnesyltransferase 1, is an enzyme crucial in the process of cholesterol biosynthesis. Its significant involvement in tumor metabolism has garnered considerable interest. The significance of FDFT1 in cancer metabolism cannot be overstated, as it actively interacts with cancer cells.