100 glucose ([18F]FDG) may be synthesized by a nucleophilic, electrophilic or solid-phase 18F-101 fluorination pathway, which leads to different products in terms of specific activity, by-products 102 and possible impurities. The [18F]FDG radiopharmaceutical produced by nucleophilic
USP Monographs: Fludeoxyglucose F 18 Injection
» Fludeoxyglucose F 18 Injection is a sterile, aqueous solution, suitable for intravenous administration, of 2-deoxy-2- [18 F]fluoro- D -glucose in which a portion of the molecules are labeled with radioactive 18 F (see Radiopharmaceuticals for Positron Emission Tomography—Compounding 823).
氟[18F]脱氧葡糖注射液 - 中国药典、药品标准、法规在线查询 - 蒲 …
含氟[18 F]的放射性浓度，按其标签上记载的时间，应为标示量的90.0%~110.0%。 【性状】 本品为无色澄明液体。 【鉴别】 （1）取本品适量，照半衰期测定法（通则1401）测定，半衰期 …
Review of 18 F-FDG Synthesis and Quality Control - PubMed …
18 F–FDG is a glucose analogue in which the hydroxyl group on the 2–carbon of a glucose molecule is replaced by a fluoride atom. Like glucose, 18 F–FDG is taken up into living cells by facilitated transport and then phosphorylated by hexokinase.
Synthesis, Quality Control and Stability Studies of 2-
The introduction of 2-[18 F] fluor-2-deoxy-D-glucose (18 FDG) has provided a valuable tool for the study of glucose metabolism in both normal and diseased tissue in conjunction with positron emission tomography (PET). 18 FDG is the most
Review of 18F-FDG Synthesis and Quality Control - ResearchGate
2006年10月1日 · The quality control requirements of (18)F-FDG can be found in United States Pharmacopeia (USP), British Pharmacopeia (BP), European Pharmacopeia (EP) and the Chemistry, Manufacturing, and...
Fluorodeoxyglucose - Antec Scientific
The ALEXYS analyzer for FDG provides a reliable solution for the quality control of FDG and its by-products as required by the US and European Pharmacopeia (USP and EP). The DECADE Elite electrochemical detector in combination with a …
氟 [18F]脱氧葡糖注射液说明书_医药百科_医库
本品用于正电子发射断层显像（PET），利用病灶的异常糖代谢的特点进行定位诊断与评估。 1.用于肿瘤PET显像，评估疑似或确诊病例肿瘤的恶性程度。 2.用于冠状动脉疾病和左心室功能不全PET显像。 与其他心肌灌注显像联用，用于评估左室功能不全病例左心室的心肌活性与心肌收缩功能的可恢复性。 3.用于确定与不正常葡糖代谢相关的癫痫病人的癫痫病灶。 用药途径： 本品通过静脉注射给药。 一般情况下，空腹给药将增加脑、肿瘤对氟 [18F]脱氧葡糖的摄取，所以病人 …
氟[18F]脱氧葡糖注射液 - 百度百科
氟 [18F]-脱氧葡糖注射液是用于正电子发射断层显像 (PET)诊断的放射性药物。 氟 [18F]-脱氧葡糖以类似葡萄糖的方式从血液分布至组织，并被已糖激酶磷酸化为氟 [18F]-脱氧葡糖-6-磷酸盐。 组织中氟 [18F]-脱氧葡糖-6-磷酸盐的含量与糖酵解的速率和葡萄糖的利用成正比。 由于心脏和脑的糖解速率高，氟 [18F]-脱氧葡糖主要集聚在心脏和脑。 氟 [18F]-脱氧葡糖在心肌组织中的集聚量和葡萄糖的消耗成正比。 缺血的心肌组织会发生有意义的葡萄糖消耗和氟 [18F]-脱氧葡糖摄取。 因 …
Review of F-FDG Synthesis and Quality Control - PubMed
The quality control requirements of (18)F-FDG can be found in United States Pharmacopeia (USP), British Pharmacopeia (BP), European Pharmacopeia (EP) and the Chemistry, Manufacturing, and Controls (CMC) section from United States Food and Drug Administration (US FDA) PET draft guidance documents.